“A study of Serum levels of LDH and ALP in carcinoma breast: An Observational study”

Shrivastava, Vijay; Meena, Pratibha; Nandwani, Radhika; Meena, Shailendra

doi:10.9790/0853-1509142631

Cited by 2 publications

(1 citation statement)

References 7 publications

(4 reference statements)

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“…Previous study found that malignant lesions of breast cancer were more common in rural areas as compared to urban. (15) This could be due to poor medical aid in rural areas, lower socioeconomic status, and illiteracy. (16) These studies not agree with the present study, this disagreement may be related to a non-homogenous samples.…”

Section: Discussionmentioning

confidence: 99%

Relation of Serum Level of Lipocalin 2 to Her2/neu in Women with Breast Cancer

2020

IJFMT

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Background: Breast cancer is the most common type of cancer worldwide, being one of the leading causes morbidity in the female. (1) Lipocalin is a neutrophil gelatinase-associated lipocalin (NGAL) or lipocalin 2 that is a 25 KDa glycoprotein, which was originally identified as a covalent complex with matrix metalloproteinase-9 (MMP-9) in human neutrophil. (2) Lipocalin acts as bone-derived hormone which crosses the blood brain barrier (BBB) and acts on the hypothalamus in the brain. The human epidermal growth factor receptor 2 (HER-2/neu), has shown to have a prognostic value for the treatment with the monoclonal antibody in breast cancer. (3) Material and Method: This is a cross sectional, hospital based study. This study was carried out at the Oncology Center in Kirkuk City-Iraq from the 1 st of November 2018 to the end of June 2019. Forty-two women with breast cancer were considered as a study group. Forty-four apparently healthy women without breast cancer (relative of patients) and with a negative family history for the first and second degree relatives of breast cancer were consider as a control group, their ages were from 23 to 70 year. By using a sterile disposable syringe 10 mls of venous blood sample was drawn from each woman at morning and was kept in a plain tube and allowed to clot at room temperature, then each sample was centrifuged at 6000 rpm to obtain serum. Serum of the patients and controls had assay for lipocalin 2 and Her2/neu by ELISA. Results:The mean serum level of lipocalin 2 was significantly elevated in breast cancer women compared to control women (62.77 ± 6.1 and 23.98 ± 5.9 ng/l) respectively at a P value of 0.001. This study also reveals that the mean serum level of Her2/neu was higher in breast cancer women (33.96 ± 2.7 ng/ml) as compared with the control group (9.76 ± 1.6 ng/ml). This result was highly significant at a P value of 0.001. This study found that there was a moderate positive correlation between lipocalin with Her2/neu in breast cancer women (R: 0.33), which means that lipocalin 2 was proportionally elevated with increasing of Her2/ neu level. Conclusion:This study reveals that there was a significant positive correlation between lipocalin and Her2/ neu in breast cancer women, the r value was 0.33.

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Section: Discussionmentioning

confidence: 99%

Relation of Serum Level of Lipocalin 2 to Her2/neu in Women with Breast Cancer

2020

IJFMT

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Study on Role of Alp, LDH and Lipase as Prognostic Markers In Female Breast Cancer Patients of Saurastra Region Of Gujarat

Mehta

Rupala

Rawat

et al. 2021

IJAR

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Breast cancer is the second most common malignancy related mortality observed in women worldwide. It is multifactorial in nature having many factors including genetics, lifestyle factors, socioeconomical etc. playing role in variable occurance and heterogeneity towards treatment. Routine diagnosis for breast cancer is usually done by mammography and histopathology, but recent adavnces suggests the role of certain biomarkers such as tumour specic hormones, serum proteins, serum enzymes etc as a supplementary parameters to predict overall prognosis of the patients. In the present study, relative analysis of the levels of ALP (alkaline phosphatase), LDH (lactate dehydrogenase) and Lipase enzyme is determined among breast cancer patients at the time of diagnosis using semi automated clinical biochemistry analyzer. further correlation is done with other socio-demographic factors prevalent among the patients. For this purpose, preoperative blood samples of breast cancer patients were collected from Rajkot Cancer Hospital and study concludes that higher expression of LDH was found in 50% of breast cancer patients, while 31.81% of breast cancer patients had higher expression levels of lipase and ALP enzyme among the study population.

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“A study of Serum levels of LDH and ALP in carcinoma breast: An Observational study”

Abstract: Abstract

Cited by 2 publications

References 7 publications

Relation of Serum Level of Lipocalin 2 to Her2/neu in Women with Breast Cancer

Relation of Serum Level of Lipocalin 2 to Her2/neu in Women with Breast Cancer

Study on Role of Alp, LDH and Lipase as Prognostic Markers In Female Breast Cancer Patients of Saurastra Region Of Gujarat

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