Structure – Activity Relationship and Therapeutic Benefits of Flavonoids in the Management of Diabetes and Associated Disorders

Lodhi, Santram; Kori, Mohan Lal

doi:10.1007/s11094-021-02329-9

Cited by 9 publications

(4 citation statements)

References 208 publications

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“…Moreover, many studies further supported the results of in silico studies, where luteolin revealed a potent antihyperglycemic effect via inhibition of α-amylase [ 50 ]. In addition, luteolin showed an improved insulin action by direct activation of the PPAR pathway, by acting at the insulin signaling pathway, and GLUT4 expression in addition to the up-regulation of synaptic proteins expression and improving endothelial insulin resistance responsible for inflammation [ 51 ]. Flavonoid antihyperglycemic activity may also elicit α-glucosidase inhibition.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Possible Antioxidant, Anti-Hyperglycaemic, Anti-Alzheimer and Anti-Inflammatory Effects of Teucrium polium Aerial Parts (Lamiaceae)

Benchikha

Messaoudi²,

Larkem³

et al. 2022

Life

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Teucrium polium L. is commonly used in folk medicine to treat hypertension and diabetes and to heal wounds. The present work aimed to evaluate the different biological activities of T. polium hydroalcoholic extract, its total phenol and flavonoid content, and its mineral elements. Results showed that T. polium extract showed significant antioxidant potential in 2-diphenyl-1-picrylhydrazyl (DPPH) assay with IC50 equal to 8.68 μg/mL but with moderate activity in galvinoxyl assay with IC50 of 21.82 μg/mL and mild activity in the β-carotene assay. It also showed a pronounced anti-hyperglycemic activity using α-amylase inhibitory assay (IC50 = 111.68 µg/mL) and exceeds that of acarbose. T. polium showed excellent activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 28.69 and 4.93 μg/mL, respectively, postulating its promising anti-Alzheimer potential. The plant extract exhibited a strong anti-inflammatory effect with Bovine Serum Albumin (BSA) denaturation inhibitory potential estimated by 97.53% at 2 mg/mL, which was further confirmed by the in vivo carrageen-induced edema model. The extract revealed its richness in flavonoids and phenols, evidenced by its polyphenols content (36.35 ± 0.294 μg GAE/mg) and flavonoids (24.30 ± 0.44 μg QE/mg). It is rich in minerals necessary for human health, such as calcium, potassium, iron, sodium, magnesium, manganese and zinc. Molecular docking performed for previously identified compounds on human α-amylase, 5-lipoxygenase (5-LOX) and acetylcholine esterase confirmed the results. Thus, it can be concluded that T. polium can be a good candidate for alleviating many health-debilitating problems and can be highly beneficial in the pharmaceutical industry and medical research.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Possible Antioxidant, Anti-Hyperglycaemic, Anti-Alzheimer and Anti-Inflammatory Effects of Teucrium polium Aerial Parts (Lamiaceae)

Benchikha

Messaoudi²,

Larkem³

et al. 2022

Life

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“…It looks into problems with blood glucose regulation or glucose homeostasis. The blood glucose levels of diabetic rats were considerably raised after consumption of glucose during an OGTT in this investigation (Lodhi and Kori, 2021 ; Germoush et al, 2019 ). With intermittent fasting, starvation, and exercise intervention, the concentration of blood glucose in diabetic rats was elevated to a peak after 30 min, and then restored to fasting blood glucose ranges after 60 and 120 min.…”

Section: Discussionmentioning

confidence: 56%

Intermittent fasting and exercise therapy abates STZ‐induced diabetotoxicity in rats through modulation of adipocytokines hormone, oxidative glucose metabolic, and glycolytic pathway

Chijiokwu

Nwangwa

Oyovwi

et al. 2022

Physiological Reports

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Diabetes is a global, costly, and growing public health issue. Intermittent fasting (IF) and exercise therapy have been shown to improve insulin sensitivity (IS) in large studies, although the underlying processes are still unknown. The goal of this study, which included both nondiabetic and diabetic rats, was to look at the mechanisms of intermittent fasting and exercise in the management of diabetotoxicity. The effects of starvation and honey on the oral glucose tolerance test, insulin tolerance test, adipocytokines, oxidative glucose metabolic enzymes, glycolytic enzymes, food intake, and body weight in rats with streptozotocin‐induced diabetes were also investigated. In the nondiabetic phase, rats were administered an oral regimen of distilled water (0.5 ml/rat), honey (1 g/kg body weight), and interventions with IF, and starvation for 4 weeks while in the diabetic phase, after STZ or citrate buffer injections, interventions with IF, exercise, starvation, and honey treatment began for 4 weeks. At all OGTT and ITT points, there was a substantial rise in glucose in the STZ group. Adipocytokines hormone, oxidative glucose metabolic enzymes, glycolytic enzymes, and body weight were all affected by STZ when compared to starvation and honey, however, IF and exercise significantly reduced these alterations. In diabetic rats, intermittent fasting and exercise enhanced serum adipocytokines levels. These findings imply that adipokines modulate glycolytic/nonmitochondrial enzymes and glucose metabolic/mitochondrial dehydrogenase to mediate the antidiabetic effects of intermittent fasting and exercise.

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“…In diverse situations, alloxan mice, glucose tolerance mice, KK-Ay diabetic mice, and diabetic individuals were used as models [31]. Hereditary diabetic mice, such as the KK-Ay mice, have been utilized as a model of type II diabetes with hyperinsulinemia by certain researchers [32]. Flavonoid, Tannin, Phenolic, and Alkaloid are the most typically engaged active ingredients.…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Study of Medicinal Plants with Antidiabetic Properties

Alam

Amin

Islam

et al. 2021

JPRI

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The purpose of this research is to assess the anti-diabetic effects of several medicinal herbs. Herbal medicine has grown in popularity in both developing and developed countries over the last several years, owing to its natural origins and lack of negative effects. Even though medicinal plants have been utilized to treat diabetes mellitus from ancient times, they have been offered as abundant but untapped prospective sources for anti-diabetic medicines. It's a reality that diabetes can't be cured, and no one has ever claimed to be completely free of the disease. Diabetes mellitus is becoming a severe hazard to human health in all regions of the world due to its fast growing occurrence. Furthermore, several novel bioactive compounds derived from plants have demonstrated antidiabetic action with greater efficacy than oral hypoglycemic medicines already utilized in clinical therapy in recent years. Despite the fact that many plants are recommended, further pharmacological and chemical study is needed to fully understand the mechanism of hypoglycemic action.

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Structure – Activity Relationship and Therapeutic Benefits of Flavonoids in the Management of Diabetes and Associated Disorders

Cited by 9 publications

References 208 publications

Evaluation of Possible Antioxidant, Anti-Hyperglycaemic, Anti-Alzheimer and Anti-Inflammatory Effects of Teucrium polium Aerial Parts (Lamiaceae)

Evaluation of Possible Antioxidant, Anti-Hyperglycaemic, Anti-Alzheimer and Anti-Inflammatory Effects of Teucrium polium Aerial Parts (Lamiaceae)

Intermittent fasting and exercise therapy abates STZ‐induced diabetotoxicity in rats through modulation of adipocytokines hormone, oxidative glucose metabolic, and glycolytic pathway

A Comprehensive Study of Medicinal Plants with Antidiabetic Properties

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