Structural and biological assessment of boron doped bioactive glass nanoparticles for dental tissue applications

Rad, Rezai Moonesi; Alshemary, Ammar Z.; Evis, Zafer; Keskin, Dilek; Altunbaş, Korhan; Tezcaner, Ayşen

doi:10.1016/j.ceramint.2018.02.230

Cited by 36 publications

(38 citation statements)

References 44 publications

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“…FT‐Raman spectra of 7B‐BG showed a peak at around 1,065 cm −1 , which was believed to be the result of overlapping of characteristic vibration of B 2 O 3 groups and asymmetric stretching mode of Si─O─Si bonds (Chryssikos, Bitsis, Kapoutsis, & Kamitsos, ). FTIR results that were presented in our previous work also confirmed successful substitution of SiO 2 by B 2 O 3 (Moonesi Rad et al, ).…”

Section: Resultssupporting

confidence: 84%

“…In another study, a gradual release of B from B‐containing mesoporous BG scaffolds enhanced proliferation of osteoblasts (Wu et al, ). We previously also observed the positive effect of B‐doped BG on proliferation of hDPSCs (Moonesi Rad et al, ; Moonesi Rad et al, ; Moonesi Rad et al, )…”

Section: Discussionmentioning

confidence: 67%

“…Pure BG (0B‐BG) and 7% B‐modified BG (7B‐BG) were synthesized by the quick alkali‐mediated sol–gel method (Moonesi Rad et al, ). Composition of 0B‐BG group consisted of SiO 2 :CaO:P 2 O 5 (58:38:4 mol%).…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, it has been reported that B addition enhanced the osteogenic and odontogenic differentiation potential of dental stem cells (Demirci et al, ; Taşlı, Doğan, Demirci, & Şahin, ). In our previous study, positive effect of B‐modified bioactive glass nanoparticles (BG‐NPs) on odontogenic differentiation of hDPSCs was observed (Moonesi Rad et al, ; Moonesi Rad Atila et al, ; Moonesi Rad et al, )…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, it has been reported that B addition enhanced the osteogenic and odontogenic differentiation potential of dental stem cells (Demirci et al, 2015;Taşlı, Doğan, Demirci, & Şahin, 2013). In our previous study, positive effect of B-modified bioactive glass nanoparticles (BG-NPs) on odontogenic differentiation of hDPSCs was observed (Moonesi Rad et al, 2018;Moonesi Rad Atila et al, 2019; In recent years, asymmetric membranes with graded structure or composition have been developed as innovative systems for the regeneration of periodontal tissues. One part of these membranes facing the bone tissue is loose, and the other one that faces the epithelial tissue is dense.…”

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confidence: 97%

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Development of a novel functionally graded membrane containing boron‐modified bioactive glass nanoparticles for guided bone regeneration

Rad

Atila

Evis

et al. 2019

J Tissue Eng Regen Med

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Barrier membranes are used in periodontal tissue engineering for successful neo‐bone tissue formation and prevention of bacterial colonization. We aimed to prepare and characterize novel 7% boron‐modified bioactive glass (7B‐BG) containing bilayered membrane for this end. We hypothesized that presence of 7B‐BG could promote structural and biological properties of guided bone regeneration (GBR) membrane. Cellulose acetate (CA) layer was prepared by solvent casting, and functionally graded layer of CA/gelatin/BG nanoparticles was prepared by electrospinning. 0B‐BG, and 7B‐BG were synthesized by quick alkali‐mediated sol–gel method and were characterized by scanning electron microscopy (SEM) and Fourier‐transform Raman spectroscopy. Membranes were cross‐linked with glutaraldehyde to preserve their stability. SEM analysis showed the asymmetric nature of membranes consisting of a smooth membrane layer and a rough surface composed of 0B‐BG and 7B‐BG containing nanofibres. 7B‐BG addition increased surface wettability (from 110.5° ± 0.8 to 73.46° ± 7.6) and biodegradability of the membranes. Additionally, a significant increase in Ca–P layer formation was observed in 7B‐BG containing group after 1‐week incubation in stimulated body fluid. 7B‐BG incorporation resulted in a decrease in tensile strength and Young's modulus values. Human dental pulp stem cells showed better attachment, spreading, and proliferation on 7B‐BG containing bilayered membranes. Osteogenic differentiation analysis revealed higher alkaline phosphatase (ALP) enzyme activity of cells (~1.5‐fold), higher intracellular calcium deposition (approximately twofold), and higher calcium deposition revealed by Alizarin red staining on 7B‐BG containing bilayered membranes. Overall, results suggested that functionally graded bilayered membranes hold potential for GBR applications in regenerative dentistry.

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Section: Resultssupporting

confidence: 84%

Section: Discussionmentioning

confidence: 67%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 97%

See 3 more Smart Citations

Development of a novel functionally graded membrane containing boron‐modified bioactive glass nanoparticles for guided bone regeneration

Rad

Atila

Evis

et al. 2019

J Tissue Eng Regen Med

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Nano‐bioactive Glass: Advances and Applications

El‐Fiqi

2022

Bioactive Glasses and Glass‐Ceramics

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Incorporation of Boron in Mesoporous Bioactive Glass Nanoparticles Reduces Inflammatory Response and Delays Osteogenic Differentiation

Zheng

Fan

Torre³

et al. 2020

Part & Part Syst Charact

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Mesoporous bioactive glass nanoparticles (MBG) are multifunctional building blocks for tissue regeneration and nanomedicine applications. Incorporation of biologically active ions can endow MBG with additional functionalities toward promoted therapeutic effects. Here, boron is incorporated into MBG by using a sol–gel approach. The concentration of boron incorporated is controllable by tuning the amount of boron precursor. Two types of boron‐doped MBG, namely 10B‐ and 15B‐MBG (5.8 and 6.5 mol% of B2O3, respectively) are synthesized. Boron incorporation does not significantly influence the particle morphology. All synthesized particles exhibit a sphere‐like shape with a size ranging from 100 to 300 nm. 10B‐ and 15B‐MBG show large specific surface area (346 and 320 m² g−1, respectively) and pore volume. Both boron‐doped MBG exhibit remarkable in vitro bioactivity and noncytotoxicity. Boron incorporation is shown to reduce the inflammatory response linked to macrophages as indicated by downregulated expression of pro‐inflammatory genes. However, boron incorporation delays the osteogenic differentiation in osteoblasts as indicated by the downregulated expression of pro‐osteogenic genes. The results demonstrate the promising potential of using boron‐doped MBG to modulate inflammatory response for bone regeneration under inflammatory conditions, as shown in this study for the first time.

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Structural and biological assessment of boron doped bioactive glass nanoparticles for dental tissue applications

Cited by 36 publications

References 44 publications

Development of a novel functionally graded membrane containing boron‐modified bioactive glass nanoparticles for guided bone regeneration

Development of a novel functionally graded membrane containing boron‐modified bioactive glass nanoparticles for guided bone regeneration

Nano‐bioactive Glass: Advances and Applications

Incorporation of Boron in Mesoporous Bioactive Glass Nanoparticles Reduces Inflammatory Response and Delays Osteogenic Differentiation

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