Stromal cells in health and disease

Schildberg, Frank A.; Donnenberg, Vera S.

doi:10.1002/cyto.a.23600

Cited by 15 publications

(15 citation statements)

References 47 publications

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“…MSCs play a key role in processes important for health and disease [25]. Considering their role in multiple tissues and organs, advanced studies are dedicated to deciphering the basic biology and potential clinical applications of MSCs [26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Characterization and Comparison of Human and Ovine Mesenchymal Stromal Cells from Three Corresponding Sources

Haddouti

Randau

Hilgers

et al. 2020

IJMS

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Currently, there is an increasing focus on mesenchymal stromal cells (MSC) as therapeutic option in bone pathologies as well as in general regenerative medicine. Although human MSCs have been extensively characterized and standardized, ovine MSCs are poorly understood. This limitation hampers clinical progress, as sheep are an excellent large animal model for orthopedic studies. Our report describes a direct comparison of human and ovine MSCs from three corresponding sources under the same conditions. All MSCs presented solid growth behavior and potent immunomodulatory capacities. Additionally, we were able to identify common positive (CD29, CD44, CD73, CD90, CD105, CD166) and negative (CD14, CD34, CD45, HLA-DR) surface markers. Although both human and ovine MSCs showed strong osteogenic potential, direct comparison revealed a slower mineralization process in ovine MSCs. Regarding gene expression level, both human and ovine MSCs presented a comparable up-regulation of Runx2 and a trend toward down-regulation of Col1A during osteogenic differentiation. In summary, this side by side comparison defined phenotypic similarities and differences of human and ovine MSCs from three different sources, thereby contributing to a better characterization and standardization of ovine MSCs. The key findings shown in this report demonstrate the utility of ovine MSCs in preclinical studies for MSC-based therapies.

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Section: Discussionmentioning

confidence: 99%

Characterization and Comparison of Human and Ovine Mesenchymal Stromal Cells from Three Corresponding Sources

Haddouti

Randau

Hilgers

et al. 2020

IJMS

Self Cite

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“…There are two types of cells in all organs that make up our body -parenchymal cells responsible for the function of the organ and stromal cells that support them. Stromal cells provide tissue repair and renewal following stress, injury, illness, or aging, that is, from both intrinsic and extrinsic causes [19]. Mesenchymal stromal cells (MSCs) are defined by the International Society of Cellular Therapy (ISCT) by their (1) ability to adhere to plastic from which they can be expanded pathogenesis and adipose tissue hypertrophy.…”

Section: Stem/stromal Cellsmentioning

confidence: 99%

“…[18]. Very recently, Gentile et al MSC, AD-MSC, have published a detailed review of the use of drugs and Vaccines in COVID19 [19]. The main problem to be accepted is that the desired point has not been reached in the solution of the COVID19 pandemic.…”

Section: Introductionmentioning

confidence: 99%

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New normal: two aspects of adipose tissue in COVID-19—treat and threat?

Çöpçü¹

2020

Expert Opinion on Biological Therapy

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Introduction: Adipose-derived stromal cells (ADSCs) can be an important alternative in COVID-19 prevention, treatment, and subsequent sequelae repair. However, ACE-2 plays a common role in the pathogenesis of adipocyte hypertrophy and COVID 19. Areas covered: In this 'Perspective,' the author would like to emphasize the use of adipose tissuederived stromal cells in COVID 19 and the issues that clinicians should pay attention to in fat graft applications in terms of adipose tissue-RAS relationship. The new normal for adipose tissue in COVID 19 will be highlighted. Expert Opinion: ADSCs may potentially be used in COVID-19. However, it has been speculated that ACE2 receptors are responsible for the pathogenesis of adipose tissue overgrowth and may be a potential danger in terms of the relationship between ACE2 receptors and COVID19. We speculate that reducing the size of overgrown fat tissue by ultra-sharp blades and using near-normal adipocytes will create a 'new normal.' ARTICLE HISTORY

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“…Finally, an editorial was published by Gentile and Sterodimas in same journal. They presented for the first time that ASC and SVF can be used in the treatment of COVID-19 from a different perspective [9]. They suggested the possibility to use autologous or allogenic ASCs intravenously or directly through a ventilation mask (aeresol) [8] .With this article, we would like to look at the subject from a different point of view, and for different purposes, stromal cells originating from adipose tissue can be used and present possible advantages and disadvantages.…”

mentioning

confidence: 99%

Potential Using of Fat-derived Stromal Cells in the Treatment of Active Disease, and also, in Both Pre- and Post-Periods in COVID-19

Çöpçü¹

2020

Aging and disease

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The whole world is fighting with the COVID-19 pandemic, which traps people home, causing high business and economic losses, and above all, leads to very serious deaths. The lack of a valid, accepted treatment protocol and vaccine that leads to continued treatment searches. Leng et al published their article in the Aging and Disease journal, which demonstrates that mesenchymal stem cells (MSCs) can be used for COVID-19 treatment.Adipose tissue is one of the most important MSCs sources in the body, and adipose derived stromal cells (ADSCs) from adipose tissue are also one of the most valuable components of stromal vascular fraction (SVF). Finally, Gentile and Sterodimas, have also published their article for the potential use of SVF in COVID-19 treatment in Aging and Disease journal. Their publication has been a guide in many ways. Adipose tissuederived stromal cells have three main features: Immunomodulatory, anti-inflammatory and regenerative. Immunomodulator effects are used as a preventive in patients prone to disease; its anti-inflammatory effects may allow them to be used as a therapeutic during active disease period and finally regenerative effects to repair postdisease sequale. Those cells can be obtained not only enzymatically, but also mechanically with very benefits. They can be delivered not only systemically through the IV route but also to the target organ with a carrier. While suggesting any adipose tissue-derived treatment method possibility, the relation of adipose tissue COVID-19 should not be ignored. Because, COVID-19 shows its effect through ACE-2 and adipose tissue is very rich and important tissue in terms of ACE-2.

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Stromal cells in health and disease

Cited by 15 publications

References 47 publications

Characterization and Comparison of Human and Ovine Mesenchymal Stromal Cells from Three Corresponding Sources

Characterization and Comparison of Human and Ovine Mesenchymal Stromal Cells from Three Corresponding Sources

New normal: two aspects of adipose tissue in COVID-19—treat and threat?

Potential Using of Fat-derived Stromal Cells in the Treatment of Active Disease, and also, in Both Pre- and Post-Periods in COVID-19

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