Strobilanthes crispus Extract Reduces RespiStrobilanthes crispus Extract Reduces Respiratory Exchange Ratio in Obese Mice Fed High Fat and Low Fat Diets

Abstract

BackgroundStrobilanthes crispus (S. crispus) leaves were traditionally consumed for its body weight lowering effect. In this study, we investigated the anti-obesity effect of S. crispus leaves extract (SCE).MethodsMice (n = 48) were fed high-fat diet (HFD) for 25 weeks to induce obesity, after which half were maintained on HFD and half switched to low-fat diet (LFD)while they were given normal water (H2O) or 0.1% (w/v) SCE in water at week 0–4 which was increased to 1% (w/v) at week 5–9. Effects of treatment with SCE were compared between HFDH2O, HFDSCE, LFDH2O and LFDSCE groups. Respiratory exchange ratios (RER) were measured at weeks 0, 5 and 10. Food, water intake and body weight were measured weekly. Plasma lipid profile and organ weights were determined at week 10.ResultsSCE had significantly reduced RER at week 9 (P = 0.011). Food intake, body weight, and abdominal adipose tissue weight were not altered by SCE at weeks 5 and 10. However, significant increase in plasma and liver cholesterol (P < 0.050) was observed.ConclusionOur findings suggest that SCE induced lipolysis and body fat oxidation and increased energy expenditure. Further studies in other animal models should be done to confirm the consistency of these results.

Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

“…Consumption of a high-fat diet (HFD) causes increased lipid accumulation and contributes to various metabolic diseases such as obesity, hyperlipidemia, atherosclerosis, cardiovascular disease, type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD) (1)(2)(3)(4). HFD contains lipids that are metabolised into triglycerides and cholesterol through exogenous and endogenous pathways in the intestine and liver, respectively (5,6).…”

Anti-Obesity Effect of Dyglomera® Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced Obesity

“…These results suggested that Dyglomera ® can be used as an effective functional food for treating obesity. In addition, further studies such as a comprehensive laboratory animal monitoring system (CLAMS) [ 36 ] are needed to evaluate the effects of Dyglomera ® in activities, even circadian rhythms. Also, it is suggested that further mechanism studies through treatment with AMPK inhibitors such as compound C are needed to elucidate the AMPK-related anti-obesity biochemical mechanism of Dyglomera ® .…”