Stimulated release of calcitonin gene-related peptide from the human right atrium in patients with and without diabetes mellitus

Calcitonin Gene‐Related Peptide and Size of the Atrial Septal Defect in New‐Onset Migraine After Transcatheter Closure: Results of a Preliminary Study

“…CGRP, a neuropeptide and the most potent vasodilator known, has been proven to be released from cardiac tissues as well as from central nervous systems in guinea pigs and humans. 10,11 It has been reported to be valuable in diagnosing and predicting migraines in adults, 6 juveniles, 18 and children. 9 Yank- The number (n) and percentage (%) of the recruited subjects with the listed clinical feature in 24 migraine and 16 non-migraine headache patients.…”

“…Plasma CGRP levels have been reported to be valuable for diagnosis and prediction in pediatric and adult migraines 6‐9 . Interestingly, apart from the central nervous system, CGRP has shown to be released from cardiac tissues, including the right atria, the sinoatrial and atrioventricular nodes, and the adventitia of the coronary arteries, in guinea pigs and humans 10,11 . To the best of our knowledge, the role of plasma CGRP levels has not been evaluated in patients undergoing the procedure of ASD closure with new‐onset MHAs.…”

“…[6][7][8][9] Interestingly, apart from the central nervous system, CGRP has shown to be released from cardiac tissues, including the right atria, the sinoatrial and atrioventricular nodes, and the adventitia of the coronary arteries, in guinea pigs and humans. 10,11 To the best of our knowledge, the role of plasma CGRP levels has not been evaluated in patients undergoing the procedure of ASD closure with new-onset MHAs. The purpose of this study was to measure CGRP levels in patients before and after ASD closure and to investigate the possible predictive factors of newonset MHAs in patients undergoing transcatheter ASD closure.…”

Calcium Activity of Upper Thoracic Dorsal Root Ganglion Neurons in Zucker Diabetic Fatty Rats

“…The expression of TRPV1 has been shown to be decreased in the hearts of STZ-diabetic mice [39] although Strecker and colleagues reported unaltered capsaicin-induced CGRP release from human right atrium from subjects with diabetes [40]. …”

The Effect of High-Fat Diet and Streptozotocin-Induced Diabetes and Endurance Training on Plasma Levels of Calcitonin Gene-Related Peptide and Lactate in Rats

“…Diabetes mellitus causes the development of sensory polyneuropathy that frequently is associated with symptoms that may result from functional and structural alteration of nociceptive neurons (17). Previous studies have shown that peripheral nerve content, release of CGRP-like immunoreactivity from nerve endings (18,19) and mRNA expression of CGRP were reduced in diabetic rats (20).…”