Stem Cell Research: The Facts, the Myths and the Promises

Lo, Kirk; Chuang, Weber W.; Lamb, Dolores J.

doi:10.1097/01.ju.0000087170.97532.ff

Cited by 25 publications

(29 citation statements)

References 71 publications

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“…Although, there are clinically relevant examples of engineered tissues in various animal models including even osteomyocutaneous flaps [87], the problem of harvesting the necessary amount of stem or progenitor cells in patients compromised by their disease remains unsolved. Therefore, there is an urgent need for a supply of phenotypically and functionally well-defined stem cells of high and standardized quality for a safe clinical application [88]. This problem is targeted and could potentially be solved by using stem cell lines.…”

Section: Applications In Reconstructive Surgerymentioning

confidence: 99%

Adult stem cell lines in regenerative medicine and reconstructive surgery

Conrad¹,

Huss

2005

Journal of Surgical Research

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Section: Applications In Reconstructive Surgerymentioning

confidence: 99%

Adult stem cell lines in regenerative medicine and reconstructive surgery

Conrad¹,

Huss

2005

Journal of Surgical Research

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“…Thus, the use of BMSC is a promissory source of stem cell once it did not involve the same philosophical, ethical, and religious issues observed with the use of embryonic stem cells, and the use of hematopoietic and mesenchymal bone marrow cells opened up a new horizon in regenerative medicine (Lo et al 2003, Braun et al 2006. Consequently, there is a great enthusiasm about the possibilities of using bone marrow stem cells to treat numerous diseases in several species of animals, especially in the dogs (Suter et al 2004).…”

Section: Topic Of General Interestmentioning

confidence: 99%

Bone marrow stem cell applied in the canine veterinary clinics

Gomes

Oliveira²,

Pinheiro

et al. 2017

Pesq. Vet. Bras.

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Cell therapy represents an old therapeutic practice initiated with the transfusion of whole blood in different clinical situations. There is now a breakthrough in the study of multipotent stem cell therapy because of its functionality in regeneration of tissues, which promotes attention of the scientific community. Bone marrow is one of the main sources of multipotent stem cells, composed by hematopoietic stem cells responsible for the renewal of the cellular components of the blood, and mesenchymal stem cells that aid in the regeneration of tissues. These cells have a strong potential for the treatment of several diseases, due their main characteristics such as high plasticity, capacity for self-renewal and immunomodulation. Although, there are many studies that show good results with the use of cell therapy as a form of treatment for several diseases, some studies still show inconclusive or unsatisfactory results. Therefore, the objective of this study was to review the application of bone marrow stem cells in the canine model since improvements on the knowledge of the technique are necessary to enable its applicability with safety and efficacy.

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“…Signaling crosstalk in the control of stem cell fate Typically, mES cells are propagated in the presence of serum and in coculture with a layer of fibroblasts that provide the LIF that inhibits ES cell differentiation (Lo et al, 2003). LIF is a member of the IL6 cytokine family that signal through receptor complexes including the transmembrane receptor, gp130.…”

Section: Regulation Of Es Cells and Ncscs By Bmpmentioning

confidence: 99%

The disparate role of BMP in stem cell biology

2005

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Stem cells share several characteristics of cancer cells including loss of contact inhibition and immortality. Therefore, stem cells represent an excellent model system in which to define the molecular mechanisms underlying cancer development and progression. Several signal transduction pathways including leukemia inhibitory factor, Wnt and FGF have been demonstrated to function in stem cell self-renewal and differentiation. However, more recently bone morphogenetic proteins (BMPs) have emerged as key regulators of stem cell fate commitment. Intriguingly, BMPs have disparate roles in regulating the biology of embryonic stem (ES) cells compared with neural crest stem cells (NCSCs). Furthermore, although BMPs block neural differentiation of ES cells from both mouse and human, they contribute to self-renewal specifically in mouse ES cells. These observations strongly suggest that combinations of extracellular factors regulate stem cells, and that crosstalk between intracellular signaling pathways precisely defines stem cell fate commitment. In this review, we focus on the role of BMP signaling in mouse and human ES cells compared with NCSCs. We then discuss how the molecular effectors of BMP signaling may contribute to cancer, and thus represent potential targets for therapeutic intervention.

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Stem Cell Research: The Facts, the Myths and the Promises

Abstract: While embracing the quest for advances in biomedicine, we cannot overlook the ethical responsibility to the patient and society. Regardless of the approach to harvest or culture stem cells human therapeutic application may still be years in the future.

Cited by 25 publications

References 71 publications

Adult stem cell lines in regenerative medicine and reconstructive surgery

Adult stem cell lines in regenerative medicine and reconstructive surgery

Bone marrow stem cell applied in the canine veterinary clinics

The disparate role of BMP in stem cell biology

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