Statins. A Review on Structural Perspectives, Adverse Reactions and Relations with Non-melanoma Skin Cancer

Abstract

The present paper aims to review an important class of medicine widely used in the therapy of hypercholesterolemia, namely statins. We have presented the main adverse reactions and the relation between statins and non-melanoma skin cancer, which we consider to be a novel element in the area of possible adverse reactions.

Pharmaceutical Forms with Basil and Propolis to the Benefit of the Oral Cavity. Formulation, preparation and microbiological analysis

“…It is common knowledge that hospitals are threatened by nosocomial infections due to these killer microorganisms [11]. The adverse effects of different synthetic drugs are wellknown when they are prescribed for different diseases or comorbidities [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].The usage of natural extracts or plant derivates is desirable for their efficacy without major adverse reactions even on normal microbioma, or if needed after the informed consent even in pregnancy [30][31][32][33][34][35][36][37][38][39][40][41][42].It is possible to use these natural products under various pharmaceutical forms, some of them even retard forms, in view of reducing nosocomial infections in hospitals.…”

Formulation and Preparation of Pharmaceuticals with Anti-rheumatic Effect Using the Active Principles of Capsicum Annuum and Piper Nigrum

“…Also, starting from the observation of the antibacterial and anti-inflammatory properties, with regard to medical ethics and capitalizing the patients' informed consent [14,15], further studies could be pursued on the effectiveness at the cutaneous level in selected cases in which certain medicine cannot be administered, being counter-indicated because of tachyphylaxis, unexpected adverse reactions, intolerance, lack of response, or unexpected phenomena also described in relation to anti-inflammatory medication or medication prescribed for different comorbidities [16][17][18][19][20][21][22][23][24][25][26] Observations can be extended in the future towards the approach of in vivo/in vitro inhibition of endosymbionts, alterations of the microbiome, in dysbiosis [27][28][29][30][31][32][33]. The adjuvant role of the treatment in various infections can also be played in the future by these active principles, at first, at the experimental level, and then in vivo [34,35].…”

Nutraceutical Properties of Apples and Derived Products (Pomace, Seeds, Peels)

“…It is useful, under specific circumstances, that new substances -perhaps plant derived products of limited adverse reaction potential -and non-aggressive alternative treatments to be investigated and used [18,37,46,56] for the prevention and management of chronic diseases. is well known today to use pharmaceuticals with retarding effect in the treatment of various diseases.…”