Using the example of a higher military educational institution, we conducted an analysis of the prevalence of diseases according to ICD-10 by years of study (n = 3381). Features among local students and visitors were: in long-term trends, an increase in ear diseases (more significant among visitors) and an equal rate of decrease in skin diseases and subcutaneous tissue, injuries; in the first year, significant differences in three, 2–4 courses — in two classes of diseases, in the pathogenesis of which the state of resistance of the organism is significant (some infectious and parasitic diseases, diseases of the respiratory system, skin and subcutaneous tissue); excess incidence of local first-year students and newcomers over rates in other courses, respectively, for classes 5 and 8 of diseases; differences in the incidence rate for adjacent years of study, which is important for determining the period of adaptation to the conditions of training and adaptation against the background of acclimatization. In local students, the prevalence of diseases in the first two courses was significantly higher than by 4–5 (data from the third to fifth courses did not differ), but for disease classes XI, XIII, XIX, prevalence persisted from 1–2 years, X, XII — up to 2–3 years For visiting students, the prevalence of diseases from the first to the fourth year exceeded that in the next year. For classes I, VII, VIII, XIII and XIX, the excess persisted for 1–2 years, XI — at least 3 years, X — 4 years. Research in an initially healthy team allows us to judge the process of students' adaptation to the learning environment, as well as adaptation against the background of acclimatization. Research is promising in other regions of the country; among students studying at universities of other departments. This will provide the basis for planning preventive measures in youth groups to preserve their health and improve professional training.