1985
DOI: 10.1590/s0036-46651985000400005
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Stability of Schistosoma mansoni progeny to antischistosomal drugs

Abstract: The susceptibility of the MAP Brazilian strain (F1 to F5 progenies) of S. mansoni to four antischistosomal drugs has been reported in a previous study. In the present investigation, progeny F14 of the same strain, was tested for stability to the same 4 drugs. A new medication, Oltipraz (35,972 RP), was added to the study. Five groups of 12 mice infected with cercariae by tail immersion were treated with hycanthone, oxamniquine, niridazole, praziquantel and Oltipraz. An untreated group was used as control. Schi… Show more

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Cited by 5 publications
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“…The low fidelity of the epigenetic system means the adaptative phenotype could theoretically be loss as quickly as it appears, unless a strong selective pressure is applied. This is consistent with the observations of the metastability of hycanthone resistance in absence of drug pressure (Jansma et al, 1977; Brindley et al, 1989), and the stability of the phenotype after 3–5 successive generations of schistosomes where under drug pressure (Cioli and Pica-Mattoccia, 1984; Dias and Olivier, 1985). Basically, epigenetic variation allows to “buy time” for a few generation (in this case, 3–5) until a stable, genetically transmitted phenotype occurs.…”
Section: Discussionsupporting
confidence: 89%
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“…The low fidelity of the epigenetic system means the adaptative phenotype could theoretically be loss as quickly as it appears, unless a strong selective pressure is applied. This is consistent with the observations of the metastability of hycanthone resistance in absence of drug pressure (Jansma et al, 1977; Brindley et al, 1989), and the stability of the phenotype after 3–5 successive generations of schistosomes where under drug pressure (Cioli and Pica-Mattoccia, 1984; Dias and Olivier, 1985). Basically, epigenetic variation allows to “buy time” for a few generation (in this case, 3–5) until a stable, genetically transmitted phenotype occurs.…”
Section: Discussionsupporting
confidence: 89%
“…Three generations of selection were necessary to obtain a phenotype that was stably inherited by the progeny (Cioli and Pica-Mattoccia, 1984). The same observation was made by Dias and Olivier (1985), as in their experiments, resistance was stable only after the 5th generation (experiments were continued until 14th generation). Unfortunately, the data for the first 3–5 generations are not available but one can assume that incomplete penetrance of the phenotype was observed.…”
Section: Discussionsupporting
confidence: 77%
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