1995
DOI: 10.1016/0163-7258(95)00026-7
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Antischistosomal drugs: Past, present … and future?

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Cited by 217 publications
(221 citation statements)
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References 230 publications
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“…This study contributes additional evidence to the available information regarding the proposed mechanism of action of OXA (Cioli et al 1995). It was previously shown that an enzymatic activity present in OXA-sensitive schistosomes (but absent in drug resistant worms) could produce the covalent binding of OXA to the DNA and other macromolecules of the parasite .…”
Section: Discussionmentioning
confidence: 72%
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“…This study contributes additional evidence to the available information regarding the proposed mechanism of action of OXA (Cioli et al 1995). It was previously shown that an enzymatic activity present in OXA-sensitive schistosomes (but absent in drug resistant worms) could produce the covalent binding of OXA to the DNA and other macromolecules of the parasite .…”
Section: Discussionmentioning
confidence: 72%
“…It was previously shown that an enzymatic activity present in OXA-sensitive schistosomes (but absent in drug resistant worms) could produce the covalent binding of OXA to the DNA and other macromolecules of the parasite . It was postulated that the schistosome enzyme was inducing the formation of an OXA ester that would then spontaneously dissociate giving rise to an electrophilic moiety capable of alkylating parasite macromolecules (Cioli et al 1985(Cioli et al , 1995. The chemical nature of the postulated ester was, however, unknown and a direct identification was problematic in view of the very short half life that such an unstable compound would exhibit.…”
Section: Discussionmentioning
confidence: 99%
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“…Au cours du XX e siècle, de nombreuses drogues allant de molécules très toxiques (comme les dérivés de l'antimoine) à des composés chimiques mieux tolérés (niridazole, hycanthone, oxamniquine, metrifonate, oltipraz…) ont été utilisées tour à tour pour le traitement de la schistosomiase [2]. Depuis ces trente dernières années, la drogue la plus largement utilisée est le Praziquantel (Biltricide ® ) car elle présente de nombreux avantages.…”
Section: Les Traitements De La Schistosomiaseunclassified