1993
DOI: 10.1016/0169-4758(93)90138-6
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Drug resistance in schistosomes

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Cited by 84 publications
(51 citation statements)
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“…This strongly suggests that resistance is induced rather than selected from preexisting forms (16). The crossbreeding experiments of Cioli et al (23,25) and Pica-Mattocia et al (107) have clearly shown that oxamniquine resistance is controlled by a single autosomal recessive gene. Resistance to oxamniquine does not appear to spread easily within communities but, rather, tends to remain limited to individual cases.…”
Section: Genetics Of Drug Resistancementioning
confidence: 95%
See 1 more Smart Citation
“…This strongly suggests that resistance is induced rather than selected from preexisting forms (16). The crossbreeding experiments of Cioli et al (23,25) and Pica-Mattocia et al (107) have clearly shown that oxamniquine resistance is controlled by a single autosomal recessive gene. Resistance to oxamniquine does not appear to spread easily within communities but, rather, tends to remain limited to individual cases.…”
Section: Genetics Of Drug Resistancementioning
confidence: 95%
“…Resistance of schistosomes to oxamniquine is undisputably documented, both in vivo and in vitro (23,25). Epidemiologically, the phenomenon has remained remarkably limited to scattered areas in Brazil.…”
Section: Drug Resistance In Schistosomesmentioning
confidence: 99%
“…Massive chemotherapy with OX or PZQ (Cline et al 1982, Andrews et al 1983, Cioli et al 1993 has been one of the most important measures in the control of schistosomiasis in endemic areas. While resistance to OX is well docummented, such has not been the case for PZQ.…”
mentioning
confidence: 99%
“…Praziquantel and oxamniquine are the drugs available for the treatment of schistosomiasis [5] . However, development of resistant strains for both drugs has been reported, leading to schistosomiasis treatment failure that highlighted the importance of developing new and more effective drugs for this disease [6][7][8] . In this context, the past years have been marked by increasing search for anti-parasitic drugs from natural sources.…”
Section: Introductionmentioning
confidence: 99%