Drug resistance in schistosomes

Drug Resistance in Human Helminths: Current Situation and Lessons from Livestock

“…This strongly suggests that resistance is induced rather than selected from preexisting forms (16). The crossbreeding experiments of Cioli et al (23,25) and Pica-Mattocia et al (107) have clearly shown that oxamniquine resistance is controlled by a single autosomal recessive gene. Resistance to oxamniquine does not appear to spread easily within communities but, rather, tends to remain limited to individual cases.…”

“…Resistance of schistosomes to oxamniquine is undisputably documented, both in vivo and in vitro (23,25). Epidemiologically, the phenomenon has remained remarkably limited to scattered areas in Brazil.…”

The immunopathology of human schistosomiasis-III: immunoglobulin isotype profiles and response to praziquantel

“…Massive chemotherapy with OX or PZQ (Cline et al 1982, Andrews et al 1983, Cioli et al 1993 has been one of the most important measures in the control of schistosomiasis in endemic areas. While resistance to OX is well docummented, such has not been the case for PZQ.…”

Curcuma longa extract nanoemulsion preparation and demonstration of its in vitro activity against Schistosoma mansoni cercariae, schistosomules and adult stages

“…Praziquantel and oxamniquine are the drugs available for the treatment of schistosomiasis [5] . However, development of resistant strains for both drugs has been reported, leading to schistosomiasis treatment failure that highlighted the importance of developing new and more effective drugs for this disease [6][7][8] . In this context, the past years have been marked by increasing search for anti-parasitic drugs from natural sources.…”