Squamous cell carcinoma of the renal parenchyma presenting as hydronephrosis: a case report and review of the recent literature

Zhang, Xirong; Zhang, Yuanfeng; Ge, Chengguo; Zhang, Junyong; Liang, Ping

doi:10.1186/s12894-020-00676-5

Cited by 11 publications

(17 citation statements)

References 10 publications

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“…Although primary renal SCC is rare, our case had contiguous liver invasion by renal SCC leading to a renohepatic fistula which, to our knowledge, has not been previously reported. 2,4,5,[8][9][10][12][13][14][15][16] This case highlights the highly variable presentations of renal SCC.…”

Section: Discussionmentioning

confidence: 85%

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Renal Squamous Cell Carcinoma Presenting With Renohepatic Fistula: A Rare Amalgam

Varshney

Nalwa

Yadav

et al. 2022

TOJ

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Background: Primary squamous cell carcinoma (SCC) of the kidney, a rare malignancy that accounts for less than 1% of all urinary tract malignancies, is usually diagnosed in late stages because of the lack of characteristic clinical and imaging features and aggressive behavior. Case Report: A 66-year-old male presented with complaints of right flank pain. Imaging suggested the differential diagnoses of xanthogranulomatous pyelonephritis or renal malignancy extending into segment VI of the liver. Right subcapsular nephrectomy was performed, and nonbilious fluid from the liver cavitary lesions was drained. Histopathologic examination showed that the lesion was a renal SCC with contiguous malignant infiltration of the liver that led to a renohepatic fistula. Conclusion: Renal SCC is a rare high-grade neoplasm and can present in an unusual form with a poor prognosis.

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Section: Discussionmentioning

confidence: 85%

“…The primary treatment for renal SCC is nephrectomy, and the role of adjuvant chemotherapy or radiotherapy is uncertain. 3,13 No standard guideline is available because of the rarity of this tumor. Our patient did not consent to adjuvant therapy.…”

Section: Discussionmentioning

confidence: 99%

Renal Squamous Cell Carcinoma Presenting With Renohepatic Fistula: A Rare Amalgam

Varshney

Nalwa

Yadav

et al. 2022

TOJ

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“…4,12 In most of the cases the age of the patient was beyond 50 years. 4,5,6,7,8,12 Insidious onset of the disease and lack of any pathognomonic sign or symptom confounds the delay in diagnosis. Due to this delay in diagnosis, tumor progress in the advanced stage, as in our case, Staghorn calculi was noted and tumor extended to perinephric fat.…”

Section: Case Reportmentioning

confidence: 99%

“…3 Squamous cell carcinoma (SCC) of the renal pelvis is a rare neoplasm, accounting for only 0.5 to 0.8% of malignant renal tumors. 4,5 Although the incidence of this tumor in the kidney, is rare, whenever a renal mass is accompanied by a longstanding renal stone, and this differential diagnosis should be considered. 6 In most cases, renal SCC is associated with chronic infections, chronic renal calculi, radiotherapy, or any factor that can irritate the urothelium.…”

Section: Introductionmentioning

confidence: 99%

Squamous Cell Carcinoma in Non-Functioning Kidney Associated with Staghorn Calculi: Uncommon Presentation of Common Malignancy

Bastakoti

Lamichhane

2020

Nep. J. Cancer

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Cancers of the kidney account for 2% of all the total human cancer. Squamous cell carcinoma (SCC) of renal pelvis is a rare neoplasm, accounting for only 0.5 to 0.8% of malignant renal tumors. In most cases, renal SCC is associated with chronic infections, chronic renal calculi, radiotherapy or any factor that can irritate the urothelium. We report a female patient aged 60 years diagnosed with Right Non-functioning Kidney with Nephrolithiasis with Suspicious Mass. Histopathological diagnosis with Squamous Cell Carcinoma in Stage III with Staghorn Calculi. In long standing urolithiasis, possibility of concomitant harboring of malignancy needs to be taken into consideration.

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“…Risk factors include renal stones, infection, endogenous and exogenous chemicals, hormonal imbalance, and vitamin A deficiency [2] . In comparison, primary SCC of the kidney parenchyma is extremely rare, with only seven cases reported to date [3] , [4] , [5] , [6] , [7] , [8] , [9] . Most cases presented with advanced stage disease, showing extra-renal invasion ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Primary squamous cell carcinoma of the kidney parenchyma with ascending colon invasion: A case report and literature review

Kim

2022

International Journal of Surgery Case Reports

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Introduction Primary squamous cell carcinoma (SCC) of the kidney parenchyma is extremely rare, with only seven cases reported to date. Herein, we present a case of primary with colon invasion. Presentation of case A 61-year-old man presented right flank pain for 5 months. Computed tomography (CT) showed multiple renal stones and a necrotic mass in the lower pole of the right kidney, which was suspicious for ascending colon invasion. There was no history of radiation or occupational exposure to chemicals. Radical nephrectomy, right hemicolectomy, and lymph node dissection were performed. The kidneys showed a solid mass with multiple renal stones. The tumor comprised nests of atypical squamous cells and keratin pearls; however, the renal pelvis was normal. 18-Fluorodeoxyglucose-positron emission tomography/CT failed to demonstrate other primary site. Therefore, the patient was diagnosed as primary SCC of the kidney. The patient did not receive adjuvant therapy and was alive during follow-up for 6 months after surgery. Discussion SCC of the urinary tract is considered to be the result of squamous metaplasia of the urothelium, which may potentially progress to SCC. Squamous metaplasia may be caused by chronic irritation. However, the mechanism of SCC remains unclear. Although the prognosis of SCC is similar to that of urothelial carcinoma when compared stage for stage, SCC tends to be diagnosed at a more advanced stage. Conclusion This is a rare case of kidney SCC with adjacent organ invasion. Additional studies are required to further our understanding of this rare tumor and improve diagnosis and treatment.

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Squamous cell carcinoma of the renal parenchyma presenting as hydronephrosis: a case report and review of the recent literature

Cited by 11 publications

References 10 publications

Renal Squamous Cell Carcinoma Presenting With Renohepatic Fistula: A Rare Amalgam

Renal Squamous Cell Carcinoma Presenting With Renohepatic Fistula: A Rare Amalgam

Squamous Cell Carcinoma in Non-Functioning Kidney Associated with Staghorn Calculi: Uncommon Presentation of Common Malignancy

Primary squamous cell carcinoma of the kidney parenchyma with ascending colon invasion: A case report and literature review

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