Dunes are present in all the worlds' big rivers and form critical agents of bedload transport, constitute appreciable sources of bed roughness and flow resistance, and generate stratification that is the most common depositional element of ancient alluvium. Yet our current models of dunes are conditioned by the geometry of bedforms observed in small rivers and laboratory experiments, and in which the downstream leeside angle is often assumed to be at the angle-of-repose. Here we show, using high-resolution bathymetry from a range of the worlds great rivers, that dunes are instead characterized predominantly by low-angle leeside slopes (<10 • ), complex leeside shapes where the steepest portion is near the base of the leeside slope, a mean wavelength:height ratio greater than 100, and a height that is often only 10% of the local flow depth. This radically different shape of dunes in the world's big rivers demands that we incorporate such geometries into predictions of flow resistance and water levels, rethink the scaling relationship of dunes when reconstructing alluvial palaeoflow depths, and calls for a fundamental reappraisal of the character, and origin, of low-angle cross-stratification within ancient alluvial sediments.
The adjustment of the bankfull channel area in the Lower Yellow River has been dramatically affected by altered flow regimes caused by human activities. This paper presents a study on the effects of altered discharge and suspended sediment load on the bankfull area at Gaocun, a representative hydrometric station in the Lower Yellow River. The analysis demonstrates the cumulative effect of previous years' flow and sediment conditions on channel adjustment, a phenomenon commonly occurring in geomorphic systems due to the delayed channel response to flow and sediment conditions. A methodology for the prediction of bankfull area was developed based on the general concept that the rate of adjustment is proportional to the difference between the bankfull area and its equilibrium value. The proposed methodology is not only applicable for the prediction of the bankfull area in response to the changes in flow and sediment conditions in the Lower Yellow River, but can also be extended to other studies where the response times have a key role to play in the assessment of channel adjustment to external changes.where Q b is the bankfull discharge in ft 3 s −1 , A b is the bankfull area in ft 2 and DA is the drainage area in mi 2 . This type of relation is needed to define bankfull discharge and channel dimensions for ungauged sites and to provide the information required for the design of stream restoration projects. However, the exponents have a wide range of variation, from 0·5 to 1·04 for Q b and from 0·67 to 0·94 for A b , due to the differences in climate, geology and vegetation (Wolman
BackgroundStudies in murine models suggested that platelet desialylation was an important mechanism of thrombocytopenia during sepsis.MethodsFirst, we performed a prospective, multicenter, observational study that enrolled septic patients with or without thrombocytopenia to determine the association between platelet desialylation and thrombocytopenia in patients with sepsis, severe sepsis, and septic shock. Gender- and age-matched healthy adults were selected as normal controls in analysis of the platelet desialylation levels (study I). Next, we conducted an open-label randomized controlled trial (RCT) in which the patients who had severe sepsis with thrombocytopenia (platelet counts ≤50 × 109/L) were randomly assigned to receive antimicrobial therapy alone (control group) or antimicrobial therapy plus oseltamivir (oseltamivir group) in a 1:1 ratio (study II). The primary outcomes were platelet desialylation level at study entry, overall platelet response rate within 14 days post-randomization, and all-cause mortality within 28 days post-randomization. Secondary outcomes included platelet recovery time, the occurrence of bleeding events, and the amount of platelets transfused within 14 days post-randomization.ResultsThe platelet desialylation levels increased significantly in the 127 septic patients with thrombocytopenia compared to the 134 patients without thrombocytopenia. A platelet response was achieved in 45 of the 54 patients in the oseltamivir group (83.3%) compared with 34 of the 52 patients in the control group (65.4%; P = 0.045). The median platelet recovery time was 5 days (interquartile range 4–6) in the oseltamivir group compared with 7 days (interquartile range 5–10) in the control group (P = 0.003). The amount of platelets transfused decreased significantly in the oseltamivir group compared to the control group (P = 0.044). There was no difference in the overall 28-day mortality regardless of whether oseltamivir was used. The Sequential Organ Failure Assessment score and platelet recovery time were independent indicators of oseltamivir therapy. The main reason for all of the mortalities was multiple-organ failure.ConclusionsThrombocytopenia was associated with increased platelet desialylation in septic patients. The addition of oseltamivir could significantly increase the platelet response rate, shorten platelet recovery time, and reduce platelet transfusion.Trial registrationChinese Clinical Trial Registry, ChiCTR-IPR-16008542.Electronic supplementary materialThe online version of this article (doi:10.1186/s13045-017-0476-1) contains supplementary material, which is available to authorized users.
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