Spectrum of Lesions in Peritumoral Area in Association with Carcinoma of Breast

Abstract

Introduction: Breast cancer remains a global health problem with an increasing incidence. Breast carcinogenesis emerges by a multistep process via steps of hyperplasia, premalignant change, and in situ carcinoma. Women with proliferative breast disease have been observed to have an increased risk of breast cancer. Improved knowledge of breast carcinogenesis will provide insight for defining the high-risk groups, thus resulting in improved screening and management regimens. Materials and methods: The present study included 60 radical mastectomies for carcinoma of breast at RajaRajeswari Medical College and Hospital, Bengaluru, from August 2015 to July 2018. The primary tumor and peritumoral area were studied both grossly and microscopically for the different lesions and the results were analyzed. Observation and results: Of the 60 cases of breast carcinomas, the predominant type of carcinoma was infiltrating ductal carcinoma, no specific type (88%) (IDC, NOS). The lesions in peritumoral area were fibrocystic changes (62%), proliferative breast lesions (13%), and ductal carcinoma in situ (DCIS) (25%). Conclusion: Most of the peritumoral area showed fibrocystic changes which have a less absolute risk of 3%, whereas DCIS has an absolute lifetime risk of 25-30% transforming into carcinoma of breast, making those patients mandatory for follow-up and management.

Histopathological study of benign proliferative breast lesions in peritumoral area of carcinoma breast - experience in a tertiary care centre

“…Among the non-proliferative lesions, fibrocystic disease was more common. The finding in our study was similar to study done by Jayker SS et al [8] . Who found fibrocystic disease in 33% cases?…”

“…Most common age group in the present study was in fourth to sixth decades of life. This was similar to study conducted by Jayker SS et al [8] . In their study, most of cases were seen in the age-group of 41-60 years.…”

“…Most commonly histological type of breast carcinoma breast was IDC NST 73(85.9%). The finding in the present study was comparable to Jayker SS et al [8] Reddy et al [13] . And Wang et al [14] .…”

“…Also documented lymph nodes metastasis in 51.85%, 41%, and 57.7% respectively.Although non-proliferative disease does not appear to be associated with increased breast cancer risk, proliferative disease without atypia and with atypia (Atypical hyperplasia and sclerosing adenosis) have been associated with a 1.5-to 4-fold increased risk for breast cancer, respectively. It is also valuable in stratifying the risk of carcinoma in contralateral breast [4,8] . Most common benign proliferative lesions in peritumoral area were non proliferative breast disease 46(54.1%).…”