Spectroscopic Characterization andIn VitroAntibacterial Activity of Some Novel Metal Complexes With Schiff Base Ligands Derived From Thiosemicarbazide

Abstract

Six novel mononuclear Schiff base metal complexes of the type [ML 1 L 2 ]X and [ML 1 L 2 X], where M D Cu(II), Ni(II), Co(II), Mn(II), Zn(II), and VO(IV) have been synthesized by condensation of 1-(1-(pyridine-2-yl)ethylidene)thiosemicarbazide (L 1 ) and 1-(1-(2,4-dihydroxyphenyl)ethylidene)thiosemicarbazide (L 2 ) in the presence of divalent metal salts. The synthesized ligands and complexes were structurally characterized on the basis of elemental analysis, IR, UV-visible, 1 H NMR spectroscopy, molar conductance, magnetic susceptibility measurements, and electrochemical studies. The in vitro antibacterial study reveals that the metal complexes inhibit the growth of bacteria more than the free ligands.

Coordination Complexes of Manganese and Their Biomedical Applications

“…This may be due to a decrease in hydrogen bonding of -OH groups in C 62 (compared to free ligands) with group of the enzymes of microbes which inhibit the penitration of C 62 to the cell walls. [128] It has been reported that often the activity of a biologically active ligand decreases or completely vanishes after replacement of phenolic protons by a metal ion since the activity of a particular molecule may be due to that phenolic group. [67] An other interesting complex C 63 having molecular structure and coordiantion behaviour similar to C 59 was synthesized using guaifenesin ( a L 63 ) and 2aminoacetic acid ( b L 63 ).…”

“…C 62 proved to have lower activity compared to ligands against almost all the tested microbes (Table ). This may be due to a decrease in hydrogen bonding of ‐OH groups in C 62 (compared to free ligands) with group of the enzymes of microbes which inhibit the penitration of C 62 to the cell walls . It has been reported that often the activity of a biologically active ligand decreases or completely vanishes after replacement of phenolic protons by a metal ion since the activity of a particular molecule may be due to that phenolic group .…”

Antimicrobial Activities of Ferrocenyl Complexes: A Review

“…On the other hand, the biological activities of metal complexes have gained attention during the last two decades due to their diverse biomedical applications like antibacterial (Osman et al, 2012;Sakthilatha et al, 2015;Wakil et al, 2017), antifungal (Ran et al, 2011El-Tabl et al, 2012), cytotoxicity El-Seidy et al, 2013), antitumor (Chang et al, 2015;Rubino et al, 2016), antiviral (Abou-Melha et al, 2015, DNA cleavage (Kokare et al, 2017;Subbaraj et al, 2014), antimalarial (Hubin et al, 2014, antioxidant (Abdel-Monem et al, 2017;Lakshmi et al, 2011), analgesic and anti-inflammatory (Hoonur et al, 2010; activities. Cisplatin (6), cis-[PtCl 2 (NH 3 ) 2 ], is the most famous and the best-known example of a small molecule-metal complex that has been used in the chemotherapy for various cancer diseases (Ott and Gust, 2007).…”