Six novel mononuclear Schiff base metal complexes of the type [ML 1 L 2 ]X and [ML 1 L 2 X], where M D Cu(II), Ni(II), Co(II), Mn(II), Zn(II), and VO(IV) have been synthesized by condensation of 1-(1-(pyridine-2-yl)ethylidene)thiosemicarbazide (L 1 ) and 1-(1-(2,4-dihydroxyphenyl)ethylidene)thiosemicarbazide (L 2 ) in the presence of divalent metal salts. The synthesized ligands and complexes were structurally characterized on the basis of elemental analysis, IR, UV-visible, 1 H NMR spectroscopy, molar conductance, magnetic susceptibility measurements, and electrochemical studies. The in vitro antibacterial study reveals that the metal complexes inhibit the growth of bacteria more than the free ligands.