Spectrophotometric determination of penicillamine and carbocisteine based on formation of metal complexes

Cellulose nanofiber–titania nanocomposites as potential drug delivery systems for dermal applications

“…Association solution (3.33 ml of MQ with 0.1% Tween 20) was added to the dish that was mounted in an inclined position into the instrument and subjected to rotation so that the immobilized material was periodically wet by solution and its β-emission was registered immediately afterwards. 1μl of 33 P-marked ATP solution (resulting in 1nM of 33 P-ATP in the dish) was added after 40 min and one more portion of 2 μl of 33 P-marked ATP solution of 33 P-marked ATP solution (resulting in ~ 3 nM of 33 P-ATP in the dish) -after 23 hours, corresponding to the start of saturation in the observed adsorption. When the adsorption equilibrium was achieved (after 43 hours), the mother liquor was replaced by the dissociation solution (phosphate buffer solution (pH 7.4) with 0.1% Tween 20), and the decrease in radioactivity in the material was followed in the same way.…”

“…The measurements of uptake and release from pure cellulose nanofibers and nanocomposite based on titania and cellulose nanofibers were performed by Ridgeview Instrument AB, exploiting Ligand Tracer TM White technology, using 33 P-labeled (ATP) (adenosine 5''-triphosphate, substitution on γ-phosphorus atom, 1 ml of solution with 1mCurie total β-activity)as model compound 30,31 . A part of sample was deposited on a PMMA Petri dish as dispersion in toluene and immobilized by drying in air.…”

Spectrophotometric Sequential Injection Determination of D-Penicillamine Based on a Complexation Reaction with Nickel Ion

“…One batch procedure based on the same reaction was previously reported. 9 However, in this work the developed method has been presented, and the analytical applicability of the reaction of complexation was enhanced with particular emphasis on all advantages arising from the SIA system: simplicity of procedure, sensitivity, reliability and excellent sample throughput. In addition, the developed method allows the determination of PEN in the concentration range 3.0 × 10 -6 -2.0 × 10 -4 mol L -1 , while 8.9 × 10 -7 mol L -1 was the limit of detection.…”

“…1 PEN's therapeutic effectiveness has been investigated and welldocumented. [2][3][4][5][6] Several analytical methods have been developed for PEN determination in pharmaceutical preparations, including spectrophotometry, [7][8][9] voltammetry, 10 potentiometry, 11 amperometry, 12 fluorometry, 13,14 capillary electrophoresis, 15 and chromatography. 16,17 There are several flow systems using a spectrophotometric detector [18][19][20][21] for the determination of PEN, among them, only one is a SIA method based on complex formation between Fe(III) ion and PEN.…”

Spectrophotometric Determination of Metoprolol Tartrate in Pharmaceutical Dosage Forms on Complex Formation with Cu(II)

“…In addition, several methods have been reported for quantification of MPT in plasma using high-performance liquid chromatography (HPLC) with UV or fluorescence detection [6][7][8][9][10][11][12][13][14][15]. Colorimetric determination of some β-blocking drugs using carbon disulphide and Cu(II) ions has been reported [16]. Chloroform was used as an extractant for the formed complex.…”