Spectrophotometric Sequential Injection Determination of D-Penicillamine Based on a Complexation Reaction with Nickel Ion

Martinovic-Bevanda, Anita; Radić, Njegomir

doi:10.2116/analsci.29.669

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…To date, various methods have been developed for quantitative determination of d ‐PA including high performance liquid chromatography (HPLC), electrochemical methods, colorimetry, chemiluminescence methods, kinetic assays, and fluorescence. Specific to nanomaterial‐based fluorometry, by modifying or assembling nanomaterials, the use of these sensitive and simple detection approaches make fluorescence a popular choice with researchers .…”

Section: Introductionmentioning

confidence: 99%

Copper nanocluster‐based fluorescence enhanced determination of d‐penicillamine

Ren

Tang

et al. 2019

Luminescence

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Taking advantage of the compelling properties of D-penicillamine (D-PA) combined with copper, a method for the sensitive and selective determination of D-PA was established using copper nanocluster (Cu NC)-based fluorescence enhancement. D-PA molecules containing a thiol compound showed a strong tendency to combine with the surface of Cu NCs, causing the re-dispersion of nanoclusters and therefore fluorescence intensity was enhanced. Fluorescence enhancement efficiency of Cu NCs induced by D-PA was linear, with the D-PA concentration varying from 0.6-30 μg ml −1 (R 2 = 0.9952) and with a detection limit of 0.54 μg ml −1 . D-PA content in human urine samples was detected with recoveries of 104.8-112.99%. Fluorescence-enhanced determination of D-PA using Cu NCs was established for the first time and this rapid, easy and sensitive method should attract much attention for this application.

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Section: Introductionmentioning

confidence: 99%

Copper nanocluster‐based fluorescence enhanced determination of d‐penicillamine

Ren

Tang

et al. 2019

Luminescence

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“…Official methods (from the British Pharmacopoeia) for determination of these thiol compounds (RSH) are acid-base titration in a non-aqueous medium for PEN and redox titration for MPG and GSH (8). Other reported methods for determination of these RSH compounds in pure form and pharmaceutical formulations include spectrophotometry (9)(10)(11)(12)(13)(14)(15), fluorimetry (16)(17)(18)(19) chemiluminescence (20)(21)(22), electroanalytical techniques (23)(24)(25)(26)(27), chromatography (28)(29)(30) and flow techniques (31)(32)(33)(34)(35).…”

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confidence: 99%

Determination of penicillamine, tiopronin and glutathione in pharmaceutical formulations by kinetic spectrophotometry

2021

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A novel and simple method for the determination of penicillamine (PEN), tiopronin (mercaptopropionyl glycine, MPG) and glutathione (GSH) in pharmaceutical formulations by kinetic spectrophotometry has been developed and validated. It is based on the redox reaction where the thiol compound (RSH) reduces CuII-neocuproine complex to CuI-neocuproine complex. The non-steady state signal of the formed CuI- neocuproine complex is measured at 458 nm. The initial rate and fixed time (at 1 min) methods were validated. The calibration graph was linear in the concentration range from 8.0 × 10‒7 to 8.0 × 10‒5 mol L−1 for the initial rate method and from 6.0 × 10‒7 to 6.0 × 10−5 mol L−1 for the fixed time method, with the detection limits of 2.4 × 10−7 and 1.4 × 10‒7 mol L−1, resp. Levels of PEN, MPG and GSH in pharmaceutical formulations were successfully assayed by both methods. The advantages of the presented methods include sensitivity, short analysis time, ease of application and low cost.

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A water-soluble luminescent cesium-lead perovskite nanocrystal probe for sensitive detection of penicillamine

Yang²,

Zhao³

et al. 2022

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Spectrophotometric Sequential Injection Determination of D-Penicillamine Based on a Complexation Reaction with Nickel Ion

Cited by 6 publications

References 18 publications

Copper nanocluster‐based fluorescence enhanced determination of d‐penicillamine

Copper nanocluster‐based fluorescence enhanced determination of d‐penicillamine

Determination of penicillamine, tiopronin and glutathione in pharmaceutical formulations by kinetic spectrophotometry

A water-soluble luminescent cesium-lead perovskite nanocrystal probe for sensitive detection of penicillamine

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