A new, simple, sensitive and accurate spectrophotometric method has been developed for the assay of metoprolol tartrate (MPT), which is based on the complexation of drug with copper(II) [Cu(II)] at pH 6.0, using Britton-Robinson buffer solution, to produce a blue adduct. The latter has a maximum absorbance at 675 nm and obeys Beer's law within the concentration range 8.5-70 μg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.998) with a limit of detection of 5.56 μg/mL. The proposed procedure has been successfully applied to the determination of this drug in its tablets. In addition, the spectral data and stability constant for the binuclear copper(II) complex of MPT (Cu2MPT2Cl2) have been reported.
144 1 The article is published in the original.The cephalosporins are a class of β lactam anti biotics originally derived from Acremonium, which was previously known as Cephalosporium. Cepha losporins are sometimes grouped into generations by their antimicrobial properties. The first cepha losporins were designated first generation, whereas later, more extended spectrum cephalosporins were classified as second generation cephalosporins. Lora and Cefa are second generation, Ceft is a third generation cephalosporins [1].Abstract-A simple and direct spectrophotometric method is developed for the determination of some ceph alosporin group antibiotic drugs such as Loracarbef (Lora), Ceftazidime (Ceft), and Cefaclor (Cefa) in bulk and pharmaceutical formulations. The optimum conditions for the analysis of aqueous solutions of drugs are studied. Under the optimum conditions, the three drugs could be assayed in the concentration range 2-9 × 10 -5 , 2-6 × 10 -5 , and 3-9 × 10 -5 M for Lora, Ceft and Cefa, respectively. Detection and quantification limits are calculated. The obtained results showed good recoveries of 100.4, 107.4, and 100.7% for Lora, Ceft, and Cefa, respectively. The results obtained are compared favorably with those given by literature methods.
Abstract:A new, simple, sensitive and accurate spectrophotometric method has been developed for the assay of metoprolol tartrate (MPT), which is based on the complexation of drug with copper(II) [Cu(II)] at pH 6.0, using Britton-Robinson buffer solution, to produce a blue adduct. The latter has a maximum absorbance at 675 nm and obeys Beer's law within the concentration range 8.5-70 µg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.998) with a limit of detection of 5.56 µg/mL. The proposed procedure has been successfully applied to the determination of this drug in its tablets. In addition, the spectral data and stability constant for the binuclear copper(II) complex of MPT (Cu 2 MPT 2 Cl 2 ) have been reported.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.