Spectrophotometric Determination of Metoprolol Tartrate in Pharmaceutical Dosage Forms on Complex Formation with Cu(II)

Çeşme, Mustafa; Tarınç, Derya; Gölcü, Ayşegül

doi:10.3390/ph4070964

Cited by 14 publications

(11 citation statements)

References 27 publications

(17 reference statements)

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“…The suggested procedure has been successfully applied to the determination of this drug in its tablets. In addition, the spectral data and stability constant for the binuclear copper(II) complex of metoprolol tartrate (Cu 2 MPT 2 Cl 2 ) have been reported [6].…”

Section: Pharmacopeian Methods Of Analysis Of Metoprolol Are Presentementioning

confidence: 99%

“…Nowadays the literature contains a large number of scientific papers devoted to the quantitative determination of metoprolol and other APIs in one medical form, since metoprolol is used in combination with different APIs for the treatment of hypertension. According to the literature data, spectrophotometry[6][7][8][9][10][11], HPLC[12][13][14][15][16][17][18][19][20][21], gas chromatography[22] are the most widely used techniques for the determination of metoprolol tartrate.…”

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confidence: 99%

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Methods of Metoprolol Analysis in Drugs and Biological Fluids: Review and Suggestions

Horyn

Logoyda

2020

IJMMR

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Background. Analytical method is increasingly implemented into fundamental pharmaceutical chemistry and analysis, considering their high sensitivity, accuracy, specificity and expressiveness. Objective. Metoprolol’s analytical method development was the research goal. Methods. The sources were world recognized journals (1990-2019) and key words used as filter were “metoprolol”, “spectrophotometry” “high-performance liquid chromatography, HPLC”, “quantitative analysis”, “validation”. Results. Chromatographic methods of analysis have the highest specificity and objectivity and allow qualitative and quantitative determination of Active Pharmaceutic Ingredient (API) in combined dosage forms and biological fluids without prior components separation. The main disadvantage of the described API analysis methods is long terms from the beginning of chromatography to API release and specific solvents used as the mobile phase in HPLC. New methods development and selection such chromatographic conditions that provide high speed and high efficiency at lower pressure of the system are essential. Also, the reduction of analysis time is achieved by simplifying the conditions for sample preparation. Conclusions. Analysts are constantly working on developing new analysis methods and their optimization in order to save time and consumables, which also ensures the efficiency of the developed method. There is no monograph on the substance or dosage forms of metoprolol in SPhU. Therefore, some of the developed methods should be suggested for the SPhU monograph, which is important for ensuring pharmacopoeial quality control of medicines in Ukraine.

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Section: Pharmacopeian Methods Of Analysis Of Metoprolol Are Presentementioning

confidence: 99%

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confidence: 99%

Methods of Metoprolol Analysis in Drugs and Biological Fluids: Review and Suggestions

Horyn

Logoyda

2020

IJMMR

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“…The method of determination of metoprolol in the substance presented in the EP makes it impossible to quantify metoprolol in tablets. Several analytical methods have been reported for the determination of metoprolol, including spectrophotometry [4][5][6][7][8], high-performance liquid chromatography (HPLC) [9][10][11][12][13][14][15] and LC-MS [16][17][18]. Laboratories with a limited budget quite often use spectrophotometric methods.…”

Section: Introduction Metoprolol Tartrate Bis [(2rs)-1-[4-(2-methoxye...mentioning

confidence: 99%

Development of the spectrophotometric method for the determination of metoprolol tartrate in tablets by using bromocresol green

Horyn

Kucher

Kryskiw

et al. 2022

SR: PS

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The aim of the work was to develop and validate a spectrophotometric method for determining metoprolol tartrate in tablets based on the reaction with bromocresol green (BCG). Material and methods. Analytical equipment: two-beam UV-visible spectrophotometer Shimadzu model -UV 1800 (Japan), software UV-Probe 2.62, laboratory electronic balance RAD WAG AS 200/C, pH-meter И-160МИ. The following APIs, dosage forms, reagents and solvents were used in the work: pharmacopoeial standard sample (CRS) of metoprolol tartrate (Sigma-Aldrich, (≥ 98 %, HPLC)), BCG (Sigma-Aldrich, (≥ 98 %, HPLC)), "Metoprolol" tablets 50 mg (Kyivmedpreparat, series 0035415), "Metoprolol" 100 mg (Farmak, series 30421), methanol (Honeywell, (≥ 99.9 %, GC)), ethanol (Honeywell, (≥ 99.9 %, GC)), chloroform (Honeywell, (≥ 99.9 %, GC)), acetonitrile (Honeywell, (≥ 99.9 %, GC)), and ethyl acetate (Honeywell, (≥ 99.7 %, GC)). Results and discussion. A spectrophotometric method was developed for determining metoprolol tartrate by reaction with BCG in a methanol solution using the absorption maximum at a wavelength of 624 nm. Stoichiometric ratios of reactive components were established, which were 1:1. The developed method for the quantitative determination of metoprolol tartrate was validated following the requirements of the SPhU. The analytical method was linear in the concentration range of 5.47-38.30 μg/mL. The limit of detection and quantification were 0.41 μg/mL and 1.24 μg/mL, respectively. According to the «greenness» pictogram of the analytical method using the AGREE method, the score was 0.79, which indicates that the proposed spectrophotometric method for the determination of metoprolol was developed in compliance with the principles of «green» chemistry.Conclusions. A spectrophotometric method for determining metoprolol tartrate in tablets based on the reaction with BCG in compliance with the principles of «green» chemistry has been developed and validated. Furthermore, the developed method for the quantitative determination of metoprolol tartrate was validated following the requirements of the SPhU. In summary, the developed method has a low negative impact on the environment and can be applied for routine pharmaceutical analysis

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“…The proposed procedure has been successfully applied to the determination of this drug in its tablets. In addition, the spectral data and stability constant for the binuclear copper(II) complex of metoprolol tartrate (Cu2MPT2Cl2) have been reported 14 .…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Cefixime in Pure Form and in Syrian Pharmaceuticals Through Complexation with Cu(II)

Ramadan¹,

Mandil²,

Dahhan³

2013

Asian J. Chem.

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Spectroscopic analytical study for the determination of cefixime in pure and its Syrian pharmaceutical formations through complexation with Cu(II) in acetate buffer at pH = 7.8 has been developed. The method is based on the formation pink colour complex between cefixime and Cu(II). The maximum absorbance of the coloured complex occurred at λ = 546 nm and the molar absorptivity is 3.28 × 10 3 L mol-1 cm-1. The reaction conditions have been optimized to obtain the complex. Under optimum conditions the absorbance of complex was found to increase linearly with increase in concentrations of cefixime, which corroborated with the correlation coefficient values (1:1). The linear range of the calibration curve was 0.453-9.069 µg mL-1 with correlation coefficients = 0.9975 in all cases. Overall recoveries were of the order of 98.00-101.50 %. The limit of detection and limit of quantification was found to be 0.075 µg mL-1 and 0.22 µg mL-1 , respectively. The proposed method was simple, economic, accurate and successfully applied to the determination of cefixime in Syrian pharmaceuticals, the results obtained agree well with the contents stated on the labels.

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Spectrophotometric Determination of Metoprolol Tartrate in Pharmaceutical Dosage Forms on Complex Formation with Cu(II)

Cited by 14 publications

References 27 publications

Methods of Metoprolol Analysis in Drugs and Biological Fluids: Review and Suggestions

Methods of Metoprolol Analysis in Drugs and Biological Fluids: Review and Suggestions

Development of the spectrophotometric method for the determination of metoprolol tartrate in tablets by using bromocresol green

Spectrophotometric Determination of Cefixime in Pure Form and in Syrian Pharmaceuticals Through Complexation with Cu(II)

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