Spectrophotometric determination of dopamine in pharmaceutical formulations

Reddy, N. Rami; Sreedevi, G.; Prabhavathi, K.; Chakravarthy, I. E.

doi:10.1007/s10809-005-0080-3

Cited by 8 publications

(3 citation statements)

References 2 publications

(1 reference statement)

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“…Thus, the detection and quantification of this compound is of extreme importance for the preservation of human health and for environmental monitoring since the effects of the bioaccumulation of these neurotransmitters in aquatic animals, such as fish and other aquatic organisms. A wide range of techniques have been employed for the detection of dopamine in different matrices; the techniques applied have included spectrophotometry, chromatography, electrochemiluminescence, and electrochemical methods [5][6][7][8][9][10]. Among the aforementioned techniques employed for dopamine determination, electrochemical methods have proven to be essentially outstanding due to the following advantages that they possess over other techniques: (i) The methods exhibit relatively higher sensitivity with excellent repeatability and good stability; (ii) they require fewer or no sample preparation steps; and (iii) they are relatively less expensive to implement [11].…”

Section: Introductionmentioning

confidence: 99%

Amperometric Biosensor Based on Laccase Enzyme, Gold Nanoparticles, and Glutaraldehyde for the Determination of Dopamine in Biological and Environmental Samples

Santos

Wong

Fatibello‐Filho

et al. 2022

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The present work reports the development and application of an amperometric biosensor based on carbon paste electrode modified with laccase enzyme, glutaraldehyde, and gold nanoparticles (Lac-Glu-AuNPs/CPE) for the determination of the neurotransmitter dopamine (DA). The materials were characterized morphologically and chemically using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and cyclic voltammetry. Optimization studies were performed in order to determine the optimal amount of enzyme and pH level that can yield the best conditions of analysis. The application of the biosensor in optimal conditions using the amperometric technique yielded a linear concentration range of 8.0 × 10−7–6.2 × 10−5 mol L−1 with a limit of detection of 6.0 × 10−8 mol L−1. The proposed biosensor was successfully applied for the determination of DA in biological and environmental samples. In addition, the application of the biosensor for the conduct of electrochemical measurements showed that the sensing device has good repeatability and stability, and it does not suffer from matrix interference effects. The proposed biosensor exhibited an analytical signal of 85% after 10 days of consecutive use.

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Section: Introductionmentioning

confidence: 99%

Amperometric Biosensor Based on Laccase Enzyme, Gold Nanoparticles, and Glutaraldehyde for the Determination of Dopamine in Biological and Environmental Samples

Santos

Wong

Fatibello‐Filho

et al. 2022

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“…In addition, several approaches have been used to detect DA, such as Spectrophotometry, 8 Chromatographic analysis, 9 ChemiLuminescence, 10 electrophoresis, 11 electrochemical method. [12][13][14] Among them, the electrochemical method is the most widely used now, because of its fast detection time, simplicity, low cost, and no sample pre-treatment.…”

Section: Introductionmentioning

confidence: 99%

Amperometric Determination of Dopamine Using Activated Screen-Printed Carbon Electrodes

et al. 2015

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In this paper, we determined dopamine using screen-printed carbon electrodes (SPCEs) which was activated by 0.1 mol L −1 NaOH solution deposited on the electrode to improve the capabilities of detection. Cyclic voltammetry and differential pulse voltammetry were used to investigate the electrochemical behavior of dopamine. Cyclic voltammetry studies indicated that electrochemical oxidation of dopamine at the surface of SPCEs was decided by pH value. Different pulse voltammetry for dopamine oxidation at the SPCEs yielded a well-defined oxidation peak at 0.2 V in 0.1 mol L −1 phosphate buffer (pH 5.0). The proposed electrodes showed good selectivity for dopamine and a good linear relationship between dopamine concentration and oxidation current was obtained within the range of 2.0 × 10 −7 mol L −1 -300.0 × 10 −6 mol L −1 with a detection limit of 6.7 × 10 −8 mol L −1 (S/N = 3). In addition, the results showed that the precision in terms of reproducibility was 2.8% in the case of the activated SPCEs. The recovery rates of this technology were 95.40 to 103.4% with a relative standard deviation (RSD) was 2.7%-4.6%, indicating that this method can completely be used for detecting the practical dopamine injection sample.

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“…6 Since its discovery in the 1950s, dopamine (DA) has been considered an important neurotransmitter in the mammalian central nervous systems. [7][8][9] Quantitative determination of DA is therefore important and has been attempted by titrimetry, 10 spectrophotometry, 11 chemiluminescence, 12 potentiometry, and voltammetry. 13 Electrochemical oxidation of DA is possible at unmodified electrodes; however, disadvantages, such as fouling of the electrode surface due to oxidation products and interference from co-oxidation of ascorbic acid present in biological fluids in the same potential window have been of concern.…”

Section: Introductionmentioning

confidence: 99%

Interfacial Janus gold nanoclusters as excellent phase- and orientation-specific dopamine sensors

Biji

Patnaik

2012

Analyst

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This investigation, following our recent report on the one-pot hemi-micellar interfacial synthesis of Janus gold nanoclusters and the inter-cluster electron coupling establishing insulator-metal transition in the oriented Janus monolayers [Langmuir, 2010, 26(17), 14047], was to fabricate modified electrodes for sensing dopamine, the neurotransmitter. With a detection limit in the sub-nanomolar range, the apparent electron transfer rate constants for dopamine detection signified an intricate Janus cluster 2D phase dependency. Surface pressure as a thermodynamic variable controlled the electronic communication between the clusters as a result of varied inter-cluster distance and size, ultimately reflecting on the sensitivity and detection limit for dopamine sensing. The non-covalent nature of the ligands on the core metal clusters facilitated the overall electro-catalytic oxidation of dopamine. The notable feature of this precise work was that it established a more effective phase- and orientation-specific Janus cluster sensing than those reported through patterned gold nanowire based sensors.

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Spectrophotometric determination of dopamine in pharmaceutical formulations

Cited by 8 publications

References 2 publications

Amperometric Biosensor Based on Laccase Enzyme, Gold Nanoparticles, and Glutaraldehyde for the Determination of Dopamine in Biological and Environmental Samples

Amperometric Biosensor Based on Laccase Enzyme, Gold Nanoparticles, and Glutaraldehyde for the Determination of Dopamine in Biological and Environmental Samples

Amperometric Determination of Dopamine Using Activated Screen-Printed Carbon Electrodes

Interfacial Janus gold nanoclusters as excellent phase- and orientation-specific dopamine sensors

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