A simple, sensitive, rapid, accurate and cost effective spectrophotometric method has been developed and validated for the estimation of haloperidol in bulk drug and for its pharmaceutical formulations. The proposed method is based on the formation of chloroform extractable ion pair complex of haloperidol with bromothymol blue. The absorbance of the coloured extractable ion pair complex is measured at the wavelength of maximum absorbance 420 nm against the reagent blank. Beer’s law is obeyed over a concentration range of 20 to 100 µg/ml of haloperidol, for a linear calibration curve. Results are statistically validated and found to be reproducible.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.