Spectrophotometric Determination of Ampicillin by Ternary Complex Formation with 1,10-Phenanthroline and Copper(II)

Abu-Zuhri, Ali Z.; Rady, Adel H.; El-Shahawi, M. S.; Aldhaheri, S.M.

doi:10.1006/mchj.1994.1066

Cited by 10 publications

(3 citation statements)

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“…These methods included spectrophotometry [15][16][17][18][19][20][21][22][23][24], high performance liquid chromatography [2,9,[25][26][27][28][29], capillary eletrophoresis [30], fluorimetry [31][32][33][34][35], polarography [36][37][38][39][40] and titrimetry [41].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of the Quantitative Analysis of Ceftazidime in Powder for Injection by Infrared Spectroscopy<SUP>#</SUP>

Moreno¹,

Salgado²

2012

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Ceftazidime quantification by the infrared spectroscopy was developed and validated for pharmaceutical preparations in powder for injection. This method involved absorbance measurements of the band corresponding to aromatic ring centered by 1475-1600 cm-1. Selectivity, linearity, precision and accuracy were determined in order to validate the proposed method. It was also found that the excipient did not interfere with the assay. Calibration curve was obtained for ceftazidime at 0.5 to 7.0 mg, and mean recovery percentage was 98.98 ± 0.70. The proposed method was successfully applied to the assay of ceftazidime in powder for injection.

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Section: Introductionmentioning

confidence: 99%

Development and Validation of the Quantitative Analysis of Ceftazidime in Powder for Injection by Infrared Spectroscopy<SUP>#</SUP>

Moreno¹,

Salgado²

2012

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“…Several analytical procedures are available in literature for the analysis of antimicrobial. These methods are spectrophotometry (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13), high performance liquid chromatography (14)(15)(16)(17)(18)(19), capillary electrophoresis (20), fluorimetry (21)(22)(23)(24), polarography (25)(26)(27)(28)(29),titrimetry (30), and bioassay (31)(32). Spectrophotometric assay for determination of other cephalosporins as ceftazidime has been described (33) but no method for Cefaclor monohydrate had been previously described.…”

Section: Introductionmentioning

confidence: 99%

Comparison of HPLC and UV Spectrophotometric Methods for the Determination of Cefaclor Monohydrate in Pharmaceutical Dosages

A¹

2016

Med chem

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This paper describes the development and evaluation of a HPLC and UV spectrophotometric methods to quantify Cefaclor Monohydrate in Oral suspensions and Capsules. HPLC analysis were carried out using a C18 Knauer column and a mobile phase composed of Triethylamine: methanol: Acetonitrile: water (2: 10: 20: 68)v\v%, with a flow rate of 1.0 mL/min and UV detection at 265 nm. For the spectrophotometric analysis, water was used as solvent and the wavelength of 264 nm was selected for the detection. Both methods were found to quantify Cefaclor monohydrate in Oral suspensions and Capsules accurately. Therefore HPLC and UV methods presented the most reliable results for the analyses of Oral suspension and Capsules. IntroductionCefaclor monhydrate (CAS 56238-63-2) ( Figure 1) is a second generation cephalosporin with high antibacterial activity; it has enhanced in vitro activity against clinically important Gram-positive and Gram-negative microorganisms (1). The chemistry of cephalosporins has been widely explored because of their extensive medical applications (2). Several analytical procedures are available in literature for the analysis of antimicrobial. These methods are spectrophotometry (3-13), high performance liquid chromatography (14-19), capillary electrophoresis (20), fluorimetry (21-24), polarography (25-29),titrimetry (30), and bioassay (31-32). Spectrophotometric assay for determination of other cephalosporins as ceftazidime has been described (33) but no method for Cefaclor monohydrate had been previously described.The purpose of this study was to develop and validate analytical methods to quantify Cefaclor monohydrate in Capsules & Oral suspensions, using HPLC and UV spectrometry. The results obtained by these methods were statistically compared, by using analysis of variance (ANOVA). In addition, the reliability and feasibility of them were evaluated focusing on routine quality control analysis.

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“…For Several analytical procedures are available in the literature for the analysis of cephalosporins. These methods are spectrophotometry [18][19][20][21][22][23][24][25][26][27], high performance liquid chromatography [28][29][30][31][32], capillary electrophoresis [33], fluorimetry [34][35][36][37][38], polarography [39][40][41][42][43] and titrimetry [44].…”

Section: Introductionmentioning

confidence: 99%

Comparison of High Performance Liquid Chromatography and Three Titrimetric Methods for the Determination of Ceftazidime in Pharmaceutical Formulations

Moreno¹,

Salgado²

2012

AAC

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Three different assays for the quality control of ceftazidime in commercial formulations were developed and compared: acidimetric, iodometric and nonaqueous methods. Method validation yielding good results and included precision and accuracy, with good recovery percent ranged from 99.67 to 100.39, and R.S.D. values smaller than 2%. Results were compared to those obtained by high performance liquid chromatographic method, developed and published previously by us, and no evidence of significant difference was observed. The results obtained agreed well with the contents stated on the labels, being rapid, simple and inexpensive alternative method for the determination of ceftazidime in pharmaceutical formulations.

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Spectrophotometric Determination of Ampicillin by Ternary Complex Formation with 1,10-Phenanthroline and Copper(II)

Cited by 10 publications

References 0 publications

Development and Validation of the Quantitative Analysis of Ceftazidime in Powder for Injection by Infrared Spectroscopy<SUP>#</SUP>

Development and Validation of the Quantitative Analysis of Ceftazidime in Powder for Injection by Infrared Spectroscopy<SUP>#</SUP>

Comparison of HPLC and UV Spectrophotometric Methods for the Determination of Cefaclor Monohydrate in Pharmaceutical Dosages

Comparison of High Performance Liquid Chromatography and Three Titrimetric Methods for the Determination of Ceftazidime in Pharmaceutical Formulations

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