Comparison of High Performance Liquid Chromatography and Three Titrimetric Methods for the Determination of Ceftazidime in Pharmaceutical Formulations

Abstract

Three different assays for the quality control of ceftazidime in commercial formulations were developed and compared: acidimetric, iodometric and nonaqueous methods. Method validation yielding good results and included precision and accuracy, with good recovery percent ranged from 99.67 to 100.39, and R.S.D. values smaller than 2%. Results were compared to those obtained by high performance liquid chromatographic method, developed and published previously by us, and no evidence of significant difference was observed. The results obtained agreed well with the contents stated on the labels, being rapid, simple and inexpensive alternative method for the determination of ceftazidime in pharmaceutical formulations.