Specificity of Estimation and Prognostic Value of Glomerular Filtration Rate in Older Age Groups With Cardiovascular Pathology

Anemic syndrome is detected in 10-25% of geriatric patients, and with increasing age, there is a tendency to increase the incidence of the disease. Among the diseases that lead to the development of anemia, kidney pathology plays an important role. Progressive deterioration of kidney function in old age is associated with an increased risk of fractures, sarcopenia, and the development of cognitive impairment. Also, nephrogenic anemia aggravates the prognosis in patients with cardiovascular diseases, which is associated with an increase in myocardial ischemia, an increase in tissue hypoxia, a progression of left ventricular hypertrophy, and a decrease in left ventricular systolic function.

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Specificity of Anemic Syndrome in Geriatric Patients With Chronic Kidney Disease

Zakharova

Bulgakova

Treneva

et al. 2020

RCLD

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Sleep and Aging: Endocrine and Epigenetic Aspects

Bulgakova

Romanchuk

2020

BSP

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Along with many physiological changes during normal aging, sleep also changes. Age-related changes in sleep include: a decrease in the duration of night sleep, an increase in the frequency of falling asleep during the day, an increase in the number of night awakenings and time spent without sleep during the night, a decrease in the phase of slow sleep, etc. Most of these changes occur between the young and the middle and remain unchanged in the elderly. In addition, the circadian system and homeostatic sleep mechanisms become less stable with aging. The level and nature of the secretion of hormones acting on sleep change during normal aging, which affects the processes of sleep and wakefulness. Sleep indicators are interrelated and/or dependent on lifestyle, polymorbidity (somatic, psychological), polypharmacy, epigenetic (social, economic, environmental, etc.) factors. Increased average human life expectancy and neuroendocrine changes in physiological and pathological aging, on the one hand, epigenetic factors and electromagnetic information load/overload, on the other hand, made a significant contribution to the circadian nature of human brain neural network interaction with artificial intelligence.

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Gut Microbiota: A New Regulator of Cardiovascular Function

Bulgakova

Zakharova

Romanchuk

2021

BSP

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In studies Romanchuk N. P. from invention in 2010 (A method for producing a cereal component for an instant food product and a method for producing a functional instant food product. RF patent for invention №2423873, consisting in increasing the preventive effect on the human body through the introduction of vital food substances into a functional food product to suppress free radical activity, invasive detoxification of the human body, optimizing neurogenic regulation of vascular tone in arterial hypertension and restoring reproductive functions in males and females by optimizing the quality structure of product components), to the present (https://doi.org/10.33619/2414-2948/58/14) it has been shown that a new managed healthy biomicrobiota and personalized functional and balanced nutrition of the “brain and microbiota” is a long-term medical program of the patient, which allows the combined use of nutritional epigenetics and pharmaceuticals, and most importantly the prevention of polypharmacy. The main engine of human longevity is when microbiological memory remains stable, and the diet of functional (healthy) dietary nutrition and the structure of healthy biomicrobiota function almost unchanged. The human microbiome is a collection of all microbes that inhabit the body. The human gut microbiome is a unique collection of microorganisms that affect a number of important processes: from metabolic and immune to cognitive, and deviation of its composition from the norm leads to the development of various pathological conditions. Harmful changes in the composition or number of gut bacteria, commonly referred to as intestinal dysbacteriosis, have been associated with the development and progression of numerous diseases, including cardiovascular (CVD) diseases. Most CVD risk factors, including aging, obesity, certain dietary patterns, and sedentary lifestyles, have been shown to cause bowel dysbiosis. Dysbacteriosis is associated with gut inflammation and reduced gut barrier integrity, which in turn increases levels of circulating structural components of bacteria and microbial metabolites that may contribute to CVD development. The purpose of the present review is to summarize available data on the role of the gut microbiome in the regulation of cardiovascular function and pathological processes. Particular attention is paid to dietary-related microbiome changes, as well as cellular mechanisms by which the microbiome can alter CVD risk.

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Specificity of Estimation and Prognostic Value of Glomerular Filtration Rate in Older Age Groups With Cardiovascular Pathology

Cited by 4 publications

References 8 publications

Specificity of Anemic Syndrome in Geriatric Patients With Chronic Kidney Disease

Specificity of Anemic Syndrome in Geriatric Patients With Chronic Kidney Disease

Sleep and Aging: Endocrine and Epigenetic Aspects

Gut Microbiota: A New Regulator of Cardiovascular Function

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