Specificity of Anemic Syndrome in Geriatric Patients With Chronic Kidney Disease

Objective. For investigating the efficacy and mechanism of Roxadustat + oral iron in the treatment of elderly chronic kidney disease (CKD) complicated with anemia. Methods. A total of 100 elderly patients with CKD and anemia admitted to our hospital between April 2020 and December 2021 were enrolled as research subjects, and the patients were assigned to control group (Con group, n = 50) or experimental group (Exp group, n = 50). The patients in the Con group were given oral iron, and those in the Exp group were given Roxadustat capsule based on the Con group. Both groups were given subcutaneous injection of recombinant human erythropoietin. The clinical efficacy, anemia indexes, iron metabolism indexes, inflammatory indexes, and adverse reactions were compared between the two groups. Results. The Exp group showed a notably higher treatment effective rate than the Con group ( P < 0.05 ). After treatment, the anemia indexes, iron metabolism indexes, and inflammatory indexes in the Exp group were notably better than those in the Con group ( P < 0.05 ). The Exp group showed a notably lower incidence of adverse reactions during treatment than the Con group ( P < 0.05 ). Conclusion. Roxadustat plus oral iron yields a pronounced clinical efficacy in the therapy of elderly patients with CKD and anemia.

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Section: Introductionmentioning

confidence: 99%

“…Chronic kidney disease is a chronic structural and functional disease of the kidneys caused by damaged renal blood vessels, renal tubules, and other diseases such as glomerulonephritis [ 1 ]. There are 5 clinical stages of chronic kidney disease (CKD), of which the third stage is the turning point of the disease.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Mechanism of Roxadustat plus Oral Iron in the Treatment of Elderly Chronic Kidney Disease with Anemia

Liu

Shi

Tian

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Частота зустрічальності анемії у коморбідніх пацієнтів (включаючи хворих з ССЗ, ЦД, ХХН) за різними джерелами літератури становить 15-60% [26][27][28][29].…”

Section: вплив донаторів оксиду азоту на клінічний перебіг ішемічної ...unclassified

Influence of Nitric Oxide Donors on the Clinical Course of Coronary Heart Disease with Concomitant Anemia

Ханюков¹,

Zayats²

2022

Ukr. ž. med. bìol. sportu

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The purpose of the study was to evaluate the effect of L-arginine on the general condition of patients with coronary artery disease and anemia, on the dynamics of laboratory parameters of iron metabolism, glucose, high-sensitivity C-reactive protein, lipid metabolism and the functional state of the kidneys in particular category of patients. Materials and methods. The study involved 53 patients with coronary heart disease and anemia, aged from 56 to 85 years. The patients were randomized into two groups. The control group included 24 patients who received standard therapy for coronary heart disease and anemia. The main group included 29 patients who, in addition to standard therapy, received L-arginine intravenously and orally according to the scheme. Results and discussion. As a result of treatment, red blood counts and iron metabolism in the main and control groups normalized. A comparative analysis of iron metabolism indicators showed that during treatment, patients who received L-arginine had a more active metabolism and accumulation of iron in the body. Restoration of hemoglobin levels in patients with coronary heart disease and anemia contributed to the improvement of the general condition and well-being in both groups. But general weakness (p<0.001) and palpitations (p<0.05) after treatment were less pronounced in the main group. Observations showed the dynamics of high-sensitivity C-reactive protein, indicators of lipid metabolism and the functional state of the kidneys in the main and control groups. A significant decrease in lipidogram parameters after treatment was noted both in patients of the control and the main group; but due to the addition of L-arginine, changes in total cholesterol, high density lipoprotein and atherogenic index in the main group compared with the control group were more pronounced (from p<0.01 to p<0.001). The inclusion of statins in the standard therapy contributed to a significant decrease in the levels of high-sensitivity C-reactive protein in patients in the main group – 17.8% (p<0.001) and 11.4% (p<0.05) in the control group. Conclusion. According to the results of the study, it was found that nitric oxide donors have a beneficial effect on iron metabolism, lipid profile, high-sensitivity C-reactive protein level, the functional state of the kidneys, and, probably, on the degree of heart failure. It has been established that against the background of treatment with L-arginine, the bioavailability of orally incoming iron increases; the supply of iron in the body increases significantly; there was a trend towards normalization of lipid profile and functional state of the kidneys with significant changes in creatinine and glomerular filtration rate levels; decrease in signs of heart failure (general weakness, palpitations)

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Sleep and Aging: Endocrine and Epigenetic Aspects

Bulgakova

Romanchuk

2020

BSP

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Along with many physiological changes during normal aging, sleep also changes. Age-related changes in sleep include: a decrease in the duration of night sleep, an increase in the frequency of falling asleep during the day, an increase in the number of night awakenings and time spent without sleep during the night, a decrease in the phase of slow sleep, etc. Most of these changes occur between the young and the middle and remain unchanged in the elderly. In addition, the circadian system and homeostatic sleep mechanisms become less stable with aging. The level and nature of the secretion of hormones acting on sleep change during normal aging, which affects the processes of sleep and wakefulness. Sleep indicators are interrelated and/or dependent on lifestyle, polymorbidity (somatic, psychological), polypharmacy, epigenetic (social, economic, environmental, etc.) factors. Increased average human life expectancy and neuroendocrine changes in physiological and pathological aging, on the one hand, epigenetic factors and electromagnetic information load/overload, on the other hand, made a significant contribution to the circadian nature of human brain neural network interaction with artificial intelligence.

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Specificity of Anemic Syndrome in Geriatric Patients With Chronic Kidney Disease

Cited by 4 publications

References 7 publications

Efficacy and Mechanism of Roxadustat plus Oral Iron in the Treatment of Elderly Chronic Kidney Disease with Anemia

Efficacy and Mechanism of Roxadustat plus Oral Iron in the Treatment of Elderly Chronic Kidney Disease with Anemia

Influence of Nitric Oxide Donors on the Clinical Course of Coronary Heart Disease with Concomitant Anemia

Sleep and Aging: Endocrine and Epigenetic Aspects

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