Specific Response of the Immunoglobulins to Rubella Infection

Baublis, Joseph V.; Brown, Gordon C.

doi:10.3181/00379727-128-32979

Cited by 71 publications

(23 citation statements)

References 2 publications

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“…Vesikari & Vaheri (1968), Best et al (1969) and Desmyter, South & Rawls (1971), demonstrated HAI activity in the IgM-containing fractions obtained from early convalescent sera by centrifugation on sucrose density gradients. The indirect fluorescent antibody technique has been used to study immunoglobulin responses in acute rubella by Baublis & Brown (1968), Cohen, Ducharme, Carpenter & Deibel (1968) and Haire & Hadden (1970), all of whom showed that the IgM response was temporary in uncomplicated cases. The presence of HAI activity has also been demonstrated in the IgM fractions obtained from early convalescent sera by gel filtration through Sephadex G-200 (Gupta, Peterson, Stout & Murphy, 1971) and agarose (BiirginWolff, Hernandez & Just, 1971).…”

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 98%

“…Banatvala et al (1967) and Best, Banatvala & Watson (1969) demonstrated rubella-specific IgM in early convalescent sera by observing a fall in HAI titre after treatment with 2-mercaptoethanol which reduces IgM. Vesikari & Vaheri (1968), Best et al (1969) and Desmyter, South & Rawls (1971), demonstrated HAI activity in the IgM-containing fractions obtained from early convalescent sera by centrifugation on sucrose density gradients. The indirect fluorescent antibody technique has been used to study immunoglobulin responses in acute rubella by Baublis & Brown (1968), Cohen, Ducharme, Carpenter & Deibel (1968) and Haire & Hadden (1970), all of whom showed that the IgM response was temporary in uncomplicated cases.…”

Section: Introductionmentioning

confidence: 98%

“…Virus-specific IgA was demonstrated in acute rubella by Baublis & Brown (1968) and was still present 22 days after the rash, but no subsequent sera were tested. Biirgin-Wolff and her colleagues showed that IgA followed the same course as IgM in acute rubella and was likely to be useful as an index of recent infection.…”

Section: Introductionmentioning

confidence: 99%

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IgG, IgA and IgM responses in acute rubella determined by the immunofluorescent technique

Cradock-Watson

Bourne

Vandervelde

1972

J. Hyg.

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SUMMARYThe indirect immunofluorescent technique has been used to study the specific immunoglobulin responses in twelve adult cases of acute uncomplicated rubella. IgG, IgA and IgM antibodies increased virtually simultaneously. IgG antibody persisted throughout the period of study but showed a slight tendency to fall in titre after 7 months. IgM antibody was detected in nine cases. In these patients it was present in high titre 5-15 days after the rash but was not detected after 20 days. IgA antibody was detected in all cases. It was present in high titre 5-20 days after the rash but was no longer detectable after 29 days except in one patient who had a very low titre at 78 days. The presence of specific IgA and IgM indicates recent rubella in uncomplicated cases, and if the immunofluorescent method is used both types of antibody should be sought.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

IgG, IgA and IgM responses in acute rubella determined by the immunofluorescent technique

Cradock-Watson

Bourne

Vandervelde

1972

J. Hyg.

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“…Alguns relatam sua presença até 3 meses após a fase aguda da doença 40 . São conhecidos na literatura casos de persistência de IgM 2,4 até 52 meses do quadro agudo de rubéola adquirida durante a gravidez 19,28,42 , tendo como provável explicação o estímulo fetal ao sistema imunológico materno 5 .…”

Section: Resultsunclassified

Imunidade à rubéola: inquérito soro-epidemiológico em hospital, Estado de São Paulo - Brasil

1988

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Os títulos de anticorpos no soro pela reação de inibição da hemaglutinação para rubéola, empregando o caulim para adsorção de beta-lipoproteínas bloqueadores inespecíficos, foram determinados em funcionárias do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (Brasil), no período de 1982-1983 e confrontados com idade, cor, unidade hospitalar, local, cargo, tempo de emprego, antecedentes de rubéola ou comunicante na vigência ou não de gravidez. Participaram do estudo 1.886 funcionárias (88,9% de 2.121) tendo títulos com a distribuição: 9,6% <10,1,3% -10,3,5% -20, 5,8% -40,10,6% -80, 20,7% -160, 27,8% -320,12,6% -640, 7,3% -1.280 e 0,8% -2.560. Houve fraca associação entre títulos e quaisquer das variáveis de confrontação (P @ 0); 87,1% das funcionárias negaram antecedentes de rubéola e destas 73,9% tiveram títulos > 20; 57,6% negaram ser comunicantes e apresentaram títulos ³ 20; em 1,1% que referiram história de rubéola, os títulos foram £20; 97% negaram contacto com rubéola durante a gravidez. Houve somente um caso de malformação congênita após rubéola no primeiro trimestre da gravidez. Das 351 funcionárias sãs, e com títulos ³ 640, em 9,4% demonstrou-se IgM específica. Não foi notada flutuação significativa dos títulos em diferentes amostras em período de observação de até um ano. Conclui-se que a maioria das funcionárias é imune à rubéola (título > 20) independente de quaisquer parâmetros analisados; a presença de IgM específica em algumas funcionárias pode ser compatível com doença subclínica. Este inquérito foi considerado útil na orientação de funcionárias grávidas comunicantes de caso suspeito ou confirmado de rubéola, e para as não-grávidas e não-imunes a indicação da profilaxia pela vacina.

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