Spatially and Temporally Resolved Ambient PM2.5 in Relation to Preterm Birth

Cowell, Whitney; Colicino, Elena; Zhang, Xueying; Ledyard, Rachel; Burris, Heather H.; Hacker, Michele R.; Kloog, Itai; Just, Allan C.; Wright, Rosalind J.

doi:10.3390/toxics9120352

Cited by 4 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,19,20,23 The models used in these analyses have been well-validated and used in previous epidemiologic studies of birth outcomes. [25][26][27] We acknowledge certain limitations in our study that may affect inference or interpretability. We assigned exposure to three criteria air pollutants based on census tract of residence at birth, which may result in exposure misclassification if gestational parents spent a substantial amount of time outside of their home and outside of their census tract.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Associations between weekly gestational exposure of fine particulate matter, ozone, and nitrogen dioxide and preterm birth in a North Carolina Birth Cohort, 2003–2015

Krajewski,

Luben,

Warren

et al. 2023

Environmental Epidemiology

View full text Add to dashboard Cite

Background: Preterm birth (PTB; <37 weeks completed gestation) is associated with exposure to air pollution, though variability in association magnitude and direction across exposure windows exists. We evaluated associations between weekly gestational exposure to fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3) with PTB in a North Carolina Birth Cohort from 2003 to 2015 (N = 1,367,517). Methods: Daily average PM2.5 and daily 8-hour maximum NO2 concentration estimates were obtained from a hybrid ensemble model with a spatial resolution of 1 km2. Daily 8-hour maximum census tract-level concentration estimates for O3 were obtained from the EPA’s Fused Air Quality Surface Using Downscaling model. Air pollutant concentrations were linked by census tract to residential address at delivery and averaged across each week of pregnancy. Modified Poisson regression models with robust errors were used to estimate risk differences (RD [95% confidence intervals (CI)]) for an interquartile range increase in pollutants per 10,000 births, adjusted for potential confounders. Results: Associations were similar in magnitude across weeks. We observed positive associations for PM2.5 and O3 exposures, but generally null associations with NO2. RDs ranged from 15 (95% CI = 11, 18) to 32 (27, 37) per 10,000 births for PM2.5; from −7 (−14, −1) to 0 (−5, 4) for NO2; and from 4 (1, 7) to 13 (10, 16) for O3. Conclusion: Our results show that increased PM2.5 exposure is associated with an increased risk of PTB across gestational weeks, and these associations persist in multipollutant models with NO2 and/or O3.

show abstract

Section: Discussionmentioning

confidence: 97%

“…4,19,20,23 The models used in these analyses have been well-validated and used in previous epidemiologic studies of birth outcomes. 25–27…”

Section: Discussionmentioning

confidence: 99%

Associations between weekly gestational exposure of fine particulate matter, ozone, and nitrogen dioxide and preterm birth in a North Carolina Birth Cohort, 2003–2015

Krajewski,

Luben,

Warren

et al. 2023

Environmental Epidemiology

View full text Add to dashboard Cite

show abstract

“…The study conducted by Sagiv et al. in Pennsylvania during 1997–2001 found an acute effect of exposure to PM 10 in two days and five days before delivery on the risk of PTB with no statistically significant difference [ 18 ], in addition, some studies have found PTB were positive related with air pollution, while the effects were no statistically significant [ 19 , 21 , 31 , 32 ]. This may be related to the low level of air pollution in the study area.…”

Section: Discussionmentioning

confidence: 99%

Short-term effects of air pollution exposure on the risk of preterm birth in Xi’an, China

et al. 2023

View full text Add to dashboard Cite

Introduction Long-term exposure to air pollution is known to be harmful to preterm birth (PTB), but little is known about the short-term effects. This study aims to quantify the short-term effect of particulate matter with aerodynamic diameter ≤ 2.5 μm (PM 2.5 ), ≤10 μm (PM 10 ) and nitrogen dioxide (NO 2 ) on PTB. Materials and methods A total of 18,826 singleton PTBs were collected during the study period. Poisson regression model combined with the distributed lag non-linear model was applied to evaluate the short-term effects of PTBs and air pollutants. Results Maternal exposure to NO 2 was significantly associated increased risk of PTB at Lag1 (RR: 1.025, 95%CI: 1.003–1.047). In the moving average model, maternal exposure to NO 2 significantly increased the risk of PTB at Lag01 (RR: 1.029, 95%CI: 1.004–1.054). In the cumulative model, maternal exposure to NO 2 significant increased the risk of PTB at Cum01 (RR:1.026, 95%CI: 1.002–1.051), Cum02 (RR: 1.030, 95%CI: 1.003–1.059), and Cum03 (RR: 1.033, 95%CI: 1.002–1.066). The effects of PM 2.5 , PM 10 and NO 2 on PTB were significant and greater in the cold season than the warm season. Conclusions Maternal exposure to NO 2 , PM 2.5 and PM 10 before delivery has a significant risk for PTB, particularly in the cold season. Key messages Maternal exposure to NO 2 was significant associated with an increased risk of preterm birth at the day 1 before delivery. Particle matter (PM 2.5 and PM 10 ) showed a significant short-term effect on preterm birth in the cold season. The effects of air pollutants on preterm birth was greater in the cold season compared with the warm season.

show abstract

“…The linear regression model for compositions is a close analog to the classical multivariate linear regression model; the main difference is that the compositional model simultaneously analyzes the six cell-type proportions as a single multivariate outcome, through an isometric log-ratio transformation. Previous research has demonstrated the potential differential effects of air pollution by fetal sex and trimester of exposure [ 11 , 35 – 37 ]. Therefore, we fitted an “overall” model that included all participants and separate models stratifying by child sex.…”

Section: Methodsmentioning

confidence: 99%

“…Placental molecular marks including DNA methylation have been proposed as a mechanism linking PM 2.5 to fetal growth [ 7 – 10 ]. Importantly, evidence from multiple studies suggest that the effects of exposure to air pollution can differ based on timing of exposure, with certain gestational weeks showing stronger associations than other time periods in gestation [ 8 , 11 , 12 ]. Additionally, fetal sex plays a crucial role, as evidenced by studies documenting sex-specific associations between air pollution and anthropometric and developmental outcomes in offspring [ 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study

Saddiki,

Zhang,

Colicino

et al. 2023

Clin Epigenet

Self Cite

View full text Add to dashboard Cite

Background Gestational exposure to ambient air pollution has been associated with adverse health outcomes for mothers and newborns. The placenta is a central regulator of the in utero environment that orchestrates development and postnatal life via fetal programming. Ambient air pollution contaminants can reach the placenta and have been shown to alter bulk placental tissue DNA methylation patterns. Yet the effect of air pollution on placental cell-type composition has not been examined. We aimed to investigate whether the exposure to ambient air pollution during gestation is associated with placental cell types inferred from DNA methylation profiles. Methods We leveraged data from 226 mother–infant pairs in the Programming of Intergenerational Stress Mechanisms (PRISM) longitudinal cohort in the Northeastern US. Daily concentrations of fine particulate matter (PM2.5) at 1 km spatial resolution were estimated from a spatiotemporal model developed with satellite data and linked to womens’ addresses during pregnancy and infants’ date of birth. The proportions of six cell types [syncytiotrophoblasts, trophoblasts, stromal, endothelial, Hofbauer and nucleated red blood cells (nRBCs)] were derived from placental tissue 450K DNA methylation array. We applied compositional regression to examine overall changes in placenta cell-type composition related to PM2.5 average by pregnancy trimester. We also investigated the association between PM2.5 and individual cell types using beta regression. All analyses were performed in the overall sample and stratified by infant sex adjusted for covariates. Results In male infants, first trimester (T1) PM2.5 was associated with changes in placental cell composition (p = 0.03), driven by a decrease [per one PM2.5 interquartile range (IQR)] of 0.037 in the syncytiotrophoblasts proportion (95% confidence interval (CI) [− 0.066, − 0.012]), accompanied by an increase in trophoblasts of 0.033 (95% CI: [0.009, 0.064]). In females, second and third trimester PM2.5 were associated with overall changes in placental cell-type composition (T2: p = 0.040; T3: p = 0.049), with a decrease in the nRBC proportion. Individual cell-type analysis with beta regression showed similar results with an additional association found for third trimester PM2.5 and stromal cells in females (decrease of 0.054, p = 0.024). Conclusion Gestational exposure to air pollution was associated with placenta cell composition. Further research is needed to corroborate these findings and evaluate their role in PM2.5-related impact in the placenta and consequent fetal programming.

show abstract

Spatially and Temporally Resolved Ambient PM2.5 in Relation to Preterm Birth

Cited by 4 publications

References 45 publications

Associations between weekly gestational exposure of fine particulate matter, ozone, and nitrogen dioxide and preterm birth in a North Carolina Birth Cohort, 2003–2015

Associations between weekly gestational exposure of fine particulate matter, ozone, and nitrogen dioxide and preterm birth in a North Carolina Birth Cohort, 2003–2015

Short-term effects of air pollution exposure on the risk of preterm birth in Xi’an, China

DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study

Contact Info

Product

Resources

About