Soy fiber improves lipid and carbohydrate metabolism in primary hyperlipidemic subjects☆

Lo, Grace S.; Goldberg, Andrew P.; Lim, Angelita; Grundhauser, John J.; Anderson, Carolyn; Schonfeld, Gustav

doi:10.1016/0021-9150(86)90098-5

Cited by 66 publications

(20 citation statements)

References 15 publications

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“…Animal studies have demonstrated that soy protein and soy isoflavones improve glycemic control, lower insulin requirement, and increase insulin sensitivity (Vahouny et al, 1985;Iritani et al, 1997;Wagner et al, 1997;Lavigne et al, 2000). Similar benefits have also been documented in several intervention studies with soy supplements (soy protein, soy fiber, and soy isoflavones), but results have been inconsistent (Mahalko et al, 1984;Lo et al, 1986;Hermansen et al, 2001;Jayagopal et al, 2002). One cross-sectional study has examined the effect of usual dietary intake of isoflavones on glucose metabolism and observed an inverse association with insulin level (Goodman-Gruen & Kritz-Silverstein, 2001).…”

Section: Introductionmentioning

confidence: 79%

Soyfood consumption and risk of glycosuria: a cross-sectional study within the Shanghai Women's Health Study

et al. 2004

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Objective: To assess the association between soyfood intake and risk of glycosuria. Design and methods: A cross-sectional study was conducted among participants of the Shanghai Women's Health Study, a population-based cohort study of women aged 40-70 y. Information on usual intake of soyfoods was obtained at baseline survey through an in-person interview using a validated food-frequency questionnaire. Included in this study were 39,385 cohort members screened for diabetes at the baseline survey and free of previously diagnosed diabetes, cardiovascular diseases, kidney diseases, and cancer. There were 323 women who tested positive for urine glucose. Odds ratios (ORs) and 95% confidence intervals (CIs) were employed to measure the association between soyfood intake and glycosuria using unconditional logistic regression. Setting: Urban communities of Shanghai, China. Results: Overall, soyfood intake was not related to the risk of glycosuria. Among postmenopausal women, however, intake of tofu and other soy products was inversely associated with risk of glycosuria after adjustment for potential confounders. The ORs across quintiles of intake were 1.0, 0.75 (95% CI ¼ 0.47-1.20), 0.79 (95% CI ¼ 0.51-1.25), 0.53 (95% CI ¼ 0.32-0.88), and 0.51 (95% CI ¼ 0.26-0.98; P for trend ¼ 0.05). Further analyses showed that the inverse association was primarily confined to postmenopausal women with a body mass index (BMI) of o25 kg/m 2 . The adjusted OR comparing the extreme quintiles was 0.36 (95% CI ¼ 0.13-0.97; P for trend ¼ 0.004). Conclusions: Soyfoods may play a role in the development of glycosuria, an important indicator of diabetes, among postmenopausal women with a low BMI.

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Section: Introductionmentioning

confidence: 79%

Soyfood consumption and risk of glycosuria: a cross-sectional study within the Shanghai Women's Health Study

et al. 2004

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“…Shorey et al (1985) showed that concentrated cell-wall material from soya-bean cotyledons (25 g/d) given to mildly hyperlipidaemic subjects caused a 5-1 1 YO decrease in total cholesterol compared with a starch placebo. When given at the same level to primary hyperlipidaemic subjects as an adjunct to a standard lipid-lowering diet, this material reduced the mean total cholesterol by an additional 130 mg/l over that seen with the standard diet alone (Lo et al 1986). In both cases LDL-cholesterol levels were reduced in proportion to the reduction in total cholesterol.…”

Section: Soya-bean Polysaccharidesmentioning

confidence: 99%

The Influence of Legume Seeds on Human Plasma Lipid Concentrations

Kingman

1991

Nutr. Res. Rev.

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“…Insoluble dietary fibres such as wheat bran and cellulose are widely used as commercial ingredients for fibre enrichment of food products such as baked goods and breakfast cereals, but have not demonstrated beneficial lipid-modifying effects (Anderson & Chen, 1979). One commercially successful, primarily insoluble legume fibre ingredient, soy kernel fibre, has been shown to beneficially modify serum lipids, albeit only in hypercholesterolaemic individuals (Schweizer et al, 1983;Tsai et al, 1983;Shorey et al, 1985;Lo et al, 1986;Bakhit et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Lupin kernel fibre-enriched foods beneficially modify serum lipids in men

et al. 2004

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Objective: To examine the effect of a diet containing a novel legume food ingredient, Australian sweet lupin (Lupinus angustifolius) kernel fibre (LKFibre), compared to a control diet without the addition of LKFibre, on serum lipids in men. Design: Randomized crossover dietary intervention study. Setting: Melbourne, Australia -Free-living men. Subjects: A total of 38 healthy males between the ages of 24 and 64 y completed the intervention. Intervention: Subjects consumed an LKFibre and a control diet for 1 month each. Both diets had the same background menus with seven additional experimental foods that either contained LKFibre or did not. Depending on energy intake, the LKFibre diet was designed to contain an additional 17 to 30 g/day fibre beyond that of the control diet. Results: Compared to the control diet, the LKFibre diet reduced total cholesterol (TC) (mean7s.e.m.; 4.571.7%; P ¼ 0.001), low-density lipoprotein cholesterol (LDL-C) (5.472.2%; P ¼ 0.001), TC: high-density lipoprotein cholesterol (HDL-C) (3.072.0%; P ¼ 0.006) and LDL-C:HDL-C (3.872.6%; P ¼ 0.003). No effects on HDL-C, triacylglycerols, glucose or insulin were observed. Conclusions: Addition of LKFibre to the diet provided favourable changes to some serum lipid measures in men, which, combined with its high palatability, suggest this novel ingredient may be useful in the dietary reduction of coronary heart disease risk.

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Soy fiber improves lipid and carbohydrate metabolism in primary hyperlipidemic subjects☆

Cited by 66 publications

References 15 publications

Soyfood consumption and risk of glycosuria: a cross-sectional study within the Shanghai Women's Health Study

Soyfood consumption and risk of glycosuria: a cross-sectional study within the Shanghai Women's Health Study

The Influence of Legume Seeds on Human Plasma Lipid Concentrations

Lupin kernel fibre-enriched foods beneficially modify serum lipids in men

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