Soulamarin, a New Coumarin from Stem Bark of Calophyllum soulattri

Ee, Gwendoline Cheng Lian; Mah, Siau Hui; Teh, Soek Sin; Rahmani, Mawardi; Go, Rusea; Taufiq‐Yap, Yun Hin

doi:10.3390/molecules16119721

Cited by 35 publications

(19 citation statements)

References 16 publications

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“…Some Calophyllum plants are used in traditional medicine. The biological activities of Calophyllum are due to the secondary metabolites such as xanthones [6,7], coumarins [8,9] and flavonoids [10]. Among the many biological activities possessed by the Calophyllum plants, anti-HIV [11] and anti-cancer [12] properties have attracted the most attention.…”

Section: Introductionmentioning

confidence: 99%

Venuloxanthone, a new pyranoxanthone from the stem bark of Calophyllum venulosum

Ismail

Daud

et al. 2015

Journal of Asian Natural Products Research

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Section: Introductionmentioning

confidence: 99%

Venuloxanthone, a new pyranoxanthone from the stem bark of Calophyllum venulosum

Ismail

Daud

et al. 2015

Journal of Asian Natural Products Research

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“…Previous studies revealed that it has potential inflammatory (Tsai et al, 2012), antimicrobial (Alkhamaiseh et al, 2012;Khan et al, 2002), anti-Helicobacter pylori (Souza et al, 2009) and cytotoxic (Alkhamaiseh et al, 2011;Mah et al, 2013) properties. These properties are deduced to be contributed by the bioactive secondary metabolites present in their plant extracts, especially coumarins (Ee et al, 2011;McKee et al, 1996). Coumarins isolated from Calophyllum species are well-known for numerous pharmacological effects such as anti-HIV (Spino et al, 1998), anti-bacterial (Verotta et al, 2004) and cytotoxicity (Guilet et al, 2001a;Win et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Anti-proliferative Effects of a Coumarin Benjaminin on Four Human Cancer Cell Lines

Mah¹,

Teh²,

Ismail³

et al. 2020

psr

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Cancer is a major health issue around the globe. Chemotherapy and radiation therapy are no longer the standard treatments for patients as these remedies lead to many adverse effects. Thus, the development of alternative effective drugs from lead compounds, especially natural products is necessary. This study aimed to isolate cytotoxic phytochemical constituents from a plant Calophyllum inophyllum, which has been used as traditional medicine since ancient time. The root of C. inophyllum was extracted and subjected for phytochemical constituent isolation. A coumarin, benjaminin (1) was isolated successfully from the chloroform extract and its structural elucidation was performed by spectroscopy analyses of MS, IR and NMR. The anti-proliferative effect of 1 on four cancer cell lines, leukemia (K562), stomach (SNU-1), liver (Hep-G2) and lung (NCI-H23) cancers were evaluated by using colorimetric MTT assay. Benjaminin (1) exhibited cytotoxic effects towards all cancer cells and showed the strongest inhibition towards SNU-1 cell proliferation with an IC 50 value of 70.42 μM. The outcome of this study revealed that 1 is a potential cytotoxic lead compound that could be further developed into anti-cancer drug. Thus, the study on the structure-activity relationship of 1 is highly recommended in due course to improve its anti-proliferative effects on cancer cells.

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“…Natural products serve as the lead compounds for the development of new medicine and drug discovery [5]. Calophyllum is widely used in traditional Chinese medicine to treat inflammation and rheumatism [6]. Calophyllum soulattri leaves in Indonesia are also used to rinse inflamed eyes [7].…”

Section: Introductionmentioning

confidence: 99%

“…The soulatron A compound of triterpenoid derivatives that are isolated from C. soulattri leaves is used as anti-inflammatory [8]. Xanton, coumarin, chromanone, acylphloroglucinol, terpenoids, and steroids are secondary metabolite compounds that were isolated from the genus Calophyllum [6]. Last studies have suggested that oral administration of C. soulattri leaves ethanol extract (CLE) repeatedly for 28 days did not cause an alteration in histological of the spleen [9].…”

Section: Introductionmentioning

confidence: 99%

The the Teratogenic Effects of Ethanolic Extract of Bintangur Leaves (Calophyllum Soulattri Burm. F) on Female White Rats

Fajriaty

Riza

Nugraha

et al. 2019

Asian J Pharm Clin Res

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Objectives: Drugs can cause undesired effects on the fetus during pregnancy, especially embryonic/organogenesis which could lead to defects in the fetus because some types of drugs can penetrate the placenta and will undergo biotransformation into a highly reactive compound that has the potential to become a teratogenic compound. The aim of this research was to examine the teratogenic effect of bintangur leaves (Calophyllum soulattri Burm. F) ethanol extract to Sprague Dawley strain white rats. Methods: The white rats are divided into four treatment groups: Control group was given carboxymethyl cellulose Na 1%, comparison group was given trimethoprim 360 mg/kg BW, C. soulattri leaves ethanol extract (CLE) 100 mg/kg BW, and CLE 500 mg/kg BW. The treatment was administrated since organogenesis period. Cesarian section was performed to pregnant rat at the 20th day to separate the fetuses. Observation covered body weight of pregnant rats, fetal biometric, morphological malformation, and skeletal formation. Results: CLE 100 mg/kg BW and 500 mg/kg BW did not cause any change in the number of a living fetus, body weight, and length of fetuses like the comparison group. Both doses of CLE shown have a normal skeletal formation. Resorption was found in the comparison group and CLE 100 mg/kg BW with the percentage was 65.21% and 6.67%. It was found that there is no significant difference (p<0.05) between both doses of CLE compared to control group. Conclusion: From the results, it is concluded that CLE did not have the teratogenic effect.

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Soulamarin, a New Coumarin from Stem Bark of Calophyllum soulattri

Cited by 35 publications

References 16 publications

Venuloxanthone, a new pyranoxanthone from the stem bark of Calophyllum venulosum

Venuloxanthone, a new pyranoxanthone from the stem bark of Calophyllum venulosum

Anti-proliferative Effects of a Coumarin Benjaminin on Four Human Cancer Cell Lines

The the Teratogenic Effects of Ethanolic Extract of Bintangur Leaves (Calophyllum Soulattri Burm. F) on Female White Rats

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