The the Teratogenic Effects of Ethanolic Extract of Bintangur Leaves (Calophyllum Soulattri Burm. F) on Female White Rats

Abstract

Objectives: Drugs can cause undesired effects on the fetus during pregnancy, especially embryonic/organogenesis which could lead to defects in the fetus because some types of drugs can penetrate the placenta and will undergo biotransformation into a highly reactive compound that has the potential to become a teratogenic compound. The aim of this research was to examine the teratogenic effect of bintangur leaves (Calophyllum soulattri Burm. F) ethanol extract to Sprague Dawley strain white rats.
 Methods: The white rats are divided into four treatment groups: Control group was given carboxymethyl cellulose Na 1%, comparison group was given trimethoprim 360 mg/kg BW, C. soulattri leaves ethanol extract (CLE) 100 mg/kg BW, and CLE 500 mg/kg BW. The treatment was administrated since organogenesis period. Cesarian section was performed to pregnant rat at the 20th day to separate the fetuses. Observation covered body weight of pregnant rats, fetal biometric, morphological malformation, and skeletal formation.
 Results: CLE 100 mg/kg BW and 500 mg/kg BW did not cause any change in the number of a living fetus, body weight, and length of fetuses like the comparison group. Both doses of CLE shown have a normal skeletal formation. Resorption was found in the comparison group and CLE 100 mg/kg BW with the percentage was 65.21% and 6.67%. It was found that there is no significant difference (p<0.05) between both doses of CLE compared to control group.
 Conclusion: From the results, it is concluded that CLE did not have the teratogenic effect.

Assessment of Teratogenic Effects of Sappan Wood (Caesalpinia Sappan L.) Extract In Rats (Rattus novergicus)

“…This is because the compound in sappan wood extract does not inhibiting the synthesis of folic acid. Imbalance between the bone-forming activity of osteoclasts leads to osteoporosis, increased bone loss and reduced bone replacement (Inarah Fajriaty et al 2019). Many of the bones in rodents, including rats, become ossified during the late fetal stage (Abebe et al 2021).…”

“…Journal of Biosciences Journal of Biosciences in their usage. As a result, about 2-3% of them are thought to be caused by taking the drug (Inarah Fajriaty et al 2019).…”