Some uncommon tumours

White, Charles Powell; Brunton, Charles E.

doi:10.1002/path.1700300209

Cited by 8 publications

(2 citation statements)

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“…In 1927, White et al published the first report of primary adenosquamous cell carcinoma of the colon in the English medical literature (4). From then on, apart from a few small series from large institutions, the majority of the data comes from individual case reports (5-10).…”

Section: Discussionmentioning

confidence: 99%

Gemcitabine-based chemotherapy in colon squamous cell carcinoma: A case report and literature review

Zhao

Guo

Sun

et al. 2017

Molecular and Clinical Oncology

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Abstract. Squamous cell carcinoma (SCC) originating from the colon is rare. In terms of its clinicopathological characteristics, this type of cancer has been reported to be more aggressive and have a worse prognosis compared with adenocarcinoma. We herein present a successful therapeutic approach applying neoadjuvant and adjuvant gemcitabine-based chemotherapy in a patient with colon SCC. A 58-year-old male patient received two cycles of neoadjuvant chemotherapy with a regimen including gemcitabine, oxaliplatin and capecitabine, followed by radical excision and six cycles of adjuvant chemotherapy. Contrast-enhanced computed tomography and serum tumor markers were used for reassessment and evaluation was based on the World Health Organization criteria. Following neoadjuvant chemotherapy, the mass had shrunk and the patient was classed as having stable disease. Surgery and adjuvant chemotherapy were then performed and the patient had achieved a progression-free survival of 10 months when this report was submitted. Therefore, gemcitabine may be a treatment option for colon SCC in the neoadjuvant and/or adjuvant chemotherapy setting.

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Section: Discussionmentioning

confidence: 99%

Gemcitabine-based chemotherapy in colon squamous cell carcinoma: A case report and literature review

Zhao

Guo

Sun

et al. 2017

Molecular and Clinical Oncology

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“…The total number of adenocarcinomas of the colon with benign or malignant squamous elements-adenoacanthomas and adenosquamous carcinomas-found in the literature is 24 [7,11,12,[33][34][35][36][37][38][39][40][41].…”

Section: Case 11mentioning

confidence: 99%

Squamous metaplasia in colonic adenomata: Report of two cases

Kontozoglou

1985

Journal of Surgical Oncology

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Primary squamous cell carcinoma and adenoacanthoma of the colon

Comer

Beahrs

Dockerty³

1971

Cancer

157

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Squamous cell carcinoma and adenoacanthoma rarely occur in the colon or upper rectum and are seen 0.05% as frequently as adenocarcinoma. At the Mavo Clinic, 20 patients with these lesions were seen during a 60‐year period. The most plausible explanation for the occurrence of these lesions is that glandular epithelioma is destroyed by deleterious influences and replaced by proliferation of basal cells which, with repeated destruction, undergo anaplasia and loss of ability to redifferentiate normally. The surgical treatment of these tumors is the same as that for adenocarcinoma. The 5‐year survival rate for patients with adenoacanthoma and squamous cell epithelioma is 30%, compared to 50% for patients with glandular cancers.

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Some uncommon tumours

Cited by 8 publications

References 0 publications

Gemcitabine-based chemotherapy in colon squamous cell carcinoma: A case report and literature review

Gemcitabine-based chemotherapy in colon squamous cell carcinoma: A case report and literature review

Squamous metaplasia in colonic adenomata: Report of two cases

Primary squamous cell carcinoma and adenoacanthoma of the colon

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