Primary squamous cell carcinoma and adenoacanthoma of the colon

Abstract

Squamous cell carcinoma and adenoacanthoma rarely occur in the colon or upper rectum and are seen 0.05% as frequently as adenocarcinoma. At the Mavo Clinic, 20 patients with these lesions were seen during a 60‐year period. The most plausible explanation for the occurrence of these lesions is that glandular epithelioma is destroyed by deleterious influences and replaced by proliferation of basal cells which, with repeated destruction, undergo anaplasia and loss of ability to redifferentiate normally. The surgical treatment of these tumors is the same as that for adenocarcinoma. The 5‐year survival rate for patients with adenoacanthoma and squamous cell epithelioma is 30%, compared to 50% for patients with glandular cancers.

Primary Squamous Cell Carcinoma of the Rectum Case Report with Literature Review

“…SCC of the rectum appears to affect individuals between the ages of 30 to 93 years old with mean age of 57 years (6) . A review of available report show that 66% of cases occured women and 34% in men (7) . The rarity of this disease precludes any possibility to studying and etablishing the exact etiology and pathogenesis.…”

Basaloid Squamous Cell Carcinoma of the Rectum: A Rare Entity

“…However, the prognosis of patients with colorectal SCC is difficult to establish due to the rarity of these tumors. Comer et al suggested a poorer prognosis for patients with colorectal SCC than adenocarcinoma [2]. Indeed, the colorectal SCC seems to be more frequently locally invasive and more likely to involve regional lymphatics than the adenocarcinomas, probably because of delayed diagnosis [23].…”

“…Of these, some represent extraordinarily rare lesions and may, thus, be the source of difficult decision-making in the clinical practice. Pure squamous cell carcinoma (SCC) is a histologic subtype of tumors of epithelial origin that is not uncommon in glandular organs such as lung and pancreas, but accounts for only 0.1 to 0.25 cases per 1,000 colorectal carcinomas [2][3][4][5]. After the first case report in 1919 [6], a total of 74 pure SCC of the colorectum and 147 of mixed squamous and adenosquamous cancer cases have been reported in the literature [5,[7][8][9].…”

Adenosquamous Carcinoma of the Sigmoid Colon: Report of a Case

“…6,9 Although the pathogenesis of the squamous cell carcinoma components of the colon remains controversial, 9-12 four hypotheses have been suggested as possible Abstract A case of adenosquamous carcinoma of the sigmoid colon is presented herein. An 85-year-old woman without any symptoms was admitted to our hospital to undergo detailed examinations of the colon and rectum.…”