Some Physicochemical Characteristics of Human α1-Fetoprotein

Masopust, J; Tomášová, H; Kotál, L

doi:10.1016/b978-0-08-016622-3.50008-6

Cited by 9 publications

(1 citation statement)

References 6 publications

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“…This procedure is normally followed by gel filtration on Sephadex G 150 and DEAE chromatography. Several modifications ofthis method have been published (Masopust et al, 1971b), but none avoids contamination with traces of albumin and al-globulin. Isolation by immunochemical methods has, however, been achieved by Nishi (1970), Adinolfi et al (1971), Nishi andHirai (1971), Ruoslahti and Seppala (1971), .…”

Section: Afp In Amniotic Fluidmentioning

confidence: 99%

Alpha-feto-protein during development and in disease.

Adinolfi¹,

Adinolfí²,

Lessof³

1975

Journal of Medical Genetics

107

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Section: Afp In Amniotic Fluidmentioning

confidence: 99%

Alpha-feto-protein during development and in disease.

Adinolfi¹,

Adinolfí²,

Lessof³

1975

Journal of Medical Genetics

107

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Oncofetal and Other Tumor-Associated Antigens of the Human Digestive System

Goldenberg¹

1976

Current Topics in Pathology

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Carcinofetale Antigene

Lamerz

Fateh‐Moghadam

1975

Klin Wochenschr

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Alpha-fetoprotein (AFP) is an alpha1-glycoprotein (M.W. about 65000) appearing in the fetal serum of most mammals including man during the early stages of pregnancy; 4 weeks after birth it disappears altogether or exists at very low concentrations as in the normal adult. AFP is formed in the yolk sac, the fetal liver and the gastro-intestinal tract. One of its physiological functions in fetal life is supposed to be the protection of the fetus from maternal oestrogens (oestrophilic property). The clinical significance of AFP is based on the regular and increasing production in primary liver cell carcinoma, less frequently in teratogenetic tumors where it serves as a control of therapy and course of the disease. Less frequent, minor and temporary increases in the AFP serum level occur in several primary tumors with secondary liver involvement, and in inflammatory gastro-intestinal diseases, e.g. of the liver (hepatitis, cirrhosis). AFP has an increasing importance in gynecology (gestational age, fetal distress syndrom, malformations, hydatidiform mole/chorion carcinoma). The physico-chemical properties of AFP are widely known. Both fetal and tumor AFP appear to be immunologically and biochemically identical, as are that of tissue and biological fluids. The differences observed (variants, microheterogeneity) depend mainly on the different content of sialic acid. An antigenetic relationship exists, between the AFP of most species. The immunodiffusion (Ouchterlony) is the most frequently used but relatively insensitive test (1-5 mug/ml) in finding AFP, whereas the radioimmunoassay is the most sensitive one (up to 0,25 ng/ml) and permits the determination of normal serum levels in adults (below 20 ng/ml). The serum concentration in healthy pregnant women lies up to 500 ng/ml, in patients with hepatitis, liver cirrhosis and other liver diseases mostly under 3 mug/ml, whereas in those with primary liver cell carcinoma levels up to and above 600 mg-percent have been found.

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Some Physicochemical Characteristics of Human α1-Fetoprotein

Cited by 9 publications

References 6 publications

Alpha-feto-protein during development and in disease.

Alpha-feto-protein during development and in disease.

Oncofetal and Other Tumor-Associated Antigens of the Human Digestive System

Carcinofetale Antigene

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