In 62 strains of Candida albicans cultivated from specimens of patients with recurrent vaginal candidosis or with renal transplants, the biotypes were determined according to several characters: colony morphology, production of chlamydospores, auxanogram of C- and N-substances, zymogram, growth kinetics, adherence capability, proteolytic activity, sensitivity to 6 antimycotics, and serotypes. On the basis of this typing system the endogenous and exogenous sources of chronic vaginal candidosis as well as the sources of systemic candidosis in patients with renal transplants could be evaluated.
The immunologic reaction to Candida antigens was studied in 188 women aged 18-61 years. The four groups included 50 women suffering from various vaginal disorders, 50 pregnant women, 38 sterile women and 50 healthy women without candidiasis. The serum antibodies were determined by agglutination, fixation of the complement, counterimmunoelectrophoresis and immunodiffusion; allergy was determined by skin tests. A significantly higher antibody level and a stronger allergic reaction were found in women with candidiasis. The authors discuss determining immunologic reaction for diagnostic purposes and recommend isolating precipitating antibodies and performing skin tests with the mannan-protein antigens in addition to microscopy and culture.
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