Oncofetal and Other Tumor-Associated Antigens of the Human Digestive System

Pregnancy-specific β glycoprotein (SP1) in tumours of the human gastrointestinal tract

“…It is not present in similar intestinal metaplasia in non-cancer cases. The positive staining does not correspond to areas of so-called dyplasia (Morson et al, 1980) or the colonic type of metaplasia described by some authors as particularly associated with cancer (Jas & Filipe, 1980 (Goldenberg, 1976) or changes in mucosubstances (Jass & Filipe, 1980) (Skinner & Whitehead, 1981) showed some areas more typical of tubulovillous adenomas and were large. This is an indication that metaplastic polyps require a more careful examination than has hitherto been usual.…”

Immunoperoxidase staining for carcinoembryonic antigen in colonic carcinoma, osteosarcoma, and chordoma

“…Either numerous tumor cells each having low concentrations of CEA, or slow metabolism of the small amounts of CEA released into the circulation, could result in elevated plasma CEA, but negative immunoperoxidase staining for CEA. Other investigators have noted poor correlation between CEA plasma levels and concentration of CEA in a variety of different tissues [5,121. However, good correlation has been found between detection of CEA in tissue sections and measurements of CEA concentration in tissue extracts.…”

“…Although serum CEA is most often elevated in malignancies of entodermally derived tissues of the digestive tract, elevated levels also occur in malignancies of other tissues, as well as in several benign conditions. Biochemical studies have indicated that CEA is a 200,000 mol wt glycoprotein, but it has not yet been purified and current preparations probably consist of a family of closely related substances [5] . This may in part explain its serum elevation in numerous conditions, although the degree of elevation in benign disorders tends to be less than in malignant ones.…”

Alcian blue staining intestinal goblet cell antigen (GOA): A Marker for gastric signet ring cell and colonic colloidal carcinoma

“…The exact relationship of GOA with other colonic antigens (for references see [4]) must be studied by direct immunochemical comparison. Further questions to be elucidated are the chemical composition of GOA, its relationship with other goblet cell mucins [3] and the possible existence of organ-and cancer specific immunogenic determinants.…”