Immunoperoxidase staining for carcinoembryonic antigen in colonic carcinoma, osteosarcoma, and chordoma

Harrowe, David J.; Taylor, Clive R.

doi:10.1002/jso.2930160102

Cited by 8 publications

References 18 publications

(4 reference statements)

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Malignant teratoma in the brain. An immunohistochemical study

Nakamura

Satō

Nishimura

et al. 1985

Cancer

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A case of intracranial malignant teratoma found in a 27‐year‐old man was reported. This unique tumor was found in the right frontal lobe separated from the pineal region and revealed various tissue components such as stratified squamous epithelium, glandular tissues, neuron, glia, ependyma, fibro‐muscular tissue, cartilage, bone, hemangiomatous lesion, malanin‐laden cells, and some germ cell components. An immunohistochemical study demonstrated the presence of S‐100 protein, glial fibrillary acidic protein (GFAP), neuron‐specific enolase (NSE), carcinoembryonic antigen (CEA), and Factor VIII in some tumorous components. In particular, the distribution of S‐100 protein in some germ cells suggested the possibility of the neuroectodermal origin of the germ cells or, alternatively, differentiation to the neuroectoderm.

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Malignant teratoma in the brain. An immunohistochemical study

Nakamura

Satō

Nishimura

et al. 1985

Cancer

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Proliferative characteristics of intracranial and spinal tumors of developmental origin

Cho

Armond

Barnwell

et al. 1988

Cancer

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The proliferative potential of 17 intracranial and spinal tumors (six craniopharyngiomas, four chor-domas, three mature teratomas, one immature teratoma, one embryonal carcinoma, one choriocarci-noma, and one dermoid tumor) was assessed. The patients received a 30-minute to 60-minute infusion of bromodeoxyuridine (BUdR) (200 mg/m2 intravenously [ I v) at the time of surgery but before a biopsy of the tumor was performed, to label cells in the DNA synthesis phase. The labeling index (LI) was calculated by determining the percentage of BUdR-labeled cells. The mean LI of the squamous epithe-lial elements of mature teratomas, craniopharyngiomas, and the dermoid tumor were 3.1 rt 1.2%, 1.9 f 0.9%, and 2.9 rt 1.9%, respectively. As in normal epithelium, the labeled cells were located in the basal layer. These results and the clinical findings suggest that the proliferation kinetics of these tumors are similar to those of normal skin and differ from those of rapidly growing malignant neoplasms. The other tissue elements (i.e., respiratory epithelium and cartilage) also demonstrated "organized" proliferation patterns similar to those of the corresponding normal tissues. An immature teratoma, an embryonal carcinoma, and a choriocarcinoma each had a high LI (24.6 f 5.3%, 32.3 f 3.8%, and 17.0 f 4.6%, respectively), and no organized pattern of proliferation was observed. In contrast, the mean LI of the four chordomas varied from 1.5% to 5.8%, and there was an even larger variation in the LI of different areas in individual tumors (from less than 1% to 7.5%). This finding suggests that even "slow-growing" chordomas sometimes can be locally aggressive and show a high incidence of recurrence, regardless of morphologic similarities.

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