Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with inflammatory bowel disease

Song, Weimin; Lv, Yonghui; Zhang, Zhen-Shu; Li, Yanan; Xiao, Liping; Yu, Xueying; Wang, Yuan‐Yuan; Hong-li, JI; Ma, Li

doi:10.3748/wjg.15.3916

Cited by 70 publications

(58 citation statements)

References 13 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…S2) showed poor changes on expression of zonula occluden 1 (ZO1) and occludin proteins between the GM and NM groups. Close attention has been paid to the relationship between the changes in intestinal permeability and the development of disease, and it was reported that animals with inflammatory bowel disease (IBD) showed higher levels of serum DAO than healthy controls33. However, this experiment showed that there were no unintended effects on intestinal permeability due to the feeding of Cry2A rice.…”

Section: Resultsmentioning

confidence: 80%

Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement

Yang

He³

et al. 2013

Sci Rep

View full text Add to dashboard Cite

Bacillus thuringiensis insecticidal toxin (Bt) rice will be commercialized as a main food source. Traditional safety assessments on genetically modified products pay little attention on gastrointestinal (GI) health. More data about GI health of Bt rice must be provided to dispel public' doubts about the potential effects on human health. We constructed an improved safety assessment animal model using a basic subchronic toxicity experiment, measuring a range of parameters including microflora composition, intestinal permeability, epithelial structure, fecal enzymes, bacterial activity, and intestinal immunity. Significant differences were found between rice-fed groups and AIN93G-fed control groups in several parameters, whereas no differences were observed between genetically modified and non-genetically modified groups. No adverse effects were found on GI health resulting from genetically modified T2A-1 rice. In conclusion, this study may offer a systematic safety assessment model for GM material with respect to the effects on GI health.

show abstract

Section: Resultsmentioning

confidence: 80%

Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement

Yang

He³

et al. 2013

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Another study, however, found a significant increase of D-lactate in hospitalised patients with active IBD [6]. This difference may be explained by the fact that the patients we have included were in remission.…”

Section: Discussionmentioning

confidence: 77%

L(+) and D(-) Lactate Are Increased in Plasma and Urine Samples of Type 2 Diabetes as Measured by a Simultaneous Quantification of L(+) and D(-) Lactate by Reversed-Phase Liquid Chromatography Tandem Mass Spectrometry

Scheijen

Hanssen

Waarenburg

et al. 2012

Experimental Diabetes Research

View full text Add to dashboard Cite

Background. Plasma and urinary levels of D-lactate have been linked to the presence of diabetes. Previously developed techniques have shown several limitations to further evaluate D-lactate as a biomarker for this condition.Methods. D- and L-lactate were quantified using ultraperformance liquid chromatography tandem mass spectrometry with labelled internal standard. Samples were derivatized with diacetyl-L-tartaric anhydride and separated on a C18-reversed phase column. D- and L-lactate were analysed in plasma and urine of controls, patients with inflammatory bowel disease (IBD), and patients with type 2 diabetes (T2DM).Results. Quantitative analysis of D- and L-lactate was achieved successfully. Calibration curves were linear (r2>0.99) over the physiological and pathophysiological ranges. Recoveries for urine and plasma were between 96% and 113%. Inter- and intra-assay variations were between 2% and 9%. The limits of detection of D-lactate and L-lactate in plasma were 0.7 μmol/L and 0.2 μmol/L, respectively. The limits of detection of D-lactate and L-lactate in urine were 8.1 nmol/mmol creatinine and 4.4 nmol/mmol creatinine, respectively. Plasma and urinary levels of D- and L-lactate were increased in patients with IBD and T2DM as compared with controls.Conclusion. The presented method proved to be suitable for the quantification of D- and L-lactate and opens the possibility to explore the use of D-lactate as a biomarker.

show abstract

“…Diamine oxidase is primarily located to the small intestinal villi. When the small intestinal mucosa is damaged, increased intestinal permeability allows diamine oxidase to diffuse into blood, resulting in elevated serum diamine oxidase content . Serum d ‐lactate is another marker of gut barrier function, derived from the metabolism of intestinal indigenous flora.…”

Section: Discussionmentioning

confidence: 99%

Increased expression of nerve growth factor correlates with visceral hypersensitivity and impaired gut barrier function in diarrhoea‐predominant irritable bowel syndrome: a preliminary explorative study

Zhang

Liu

et al. 2016

Aliment Pharmacol Ther

View full text Add to dashboard Cite

BackgroundNeural-immune-endocrine network mechanism has attracted increased attention in diarrhoea-predominant irritable bowel syndrome (IBS-D). Pre-clinical evidence indicates that nerve growth factor (NGF) mediates visceral hypersensitivity and gut barrier dysfunction, via interactions with mast cells and sensory nerve fibres. AimTo explore the role of nerve growth factor, as well as mast cell-nerve growth factor-nerve interaction in IBS-D pathophysiology. MethodsIn this cross-sectional study, IBS-D patients and healthy controls first underwent clinical and psychological assessments. Visceral sensitivity to rectal distension was tested. As gut barrier function markers, serum diamine oxidase and D-lactate were detected. Rectosigmoid biopsies were taken for the analyses of nerve growth factor expression, mast cell count and activation, and sensory nerve fibres expressing transient receptor potential vanilloid 1 and calcitonin gene-related peptide. Correlations between these parameters were examined in patients. ResultsThirty-eight IBS-D patients (28 males, 10 females; average age 30.2 years) and 20 healthy controls (12 males, 8 females; average age 26.8 years) participated in the study. The patients presented increased psychological symptoms, visceral hypersensitivity and impaired gut barrier function. NGF gene expression, mast cell count and sensory nerve fibres were significantly increased in the patients (P < 0.05). In correlation analysis, NGF expression was positively correlated with the disease severity, anxiety and serum diamine oxidase; visceral sensitivity thresholds were negatively associated with NGF expression (Bonferroni corrected P < 0.0029). ConclusionsElevated mucosal NGF may interact with mast cells and sensory nerve fibres, contributing to visceral hypersensitivity and impaired gut barrier function in IBS-D.

show abstract

Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with inflammatory bowel disease

Cited by 70 publications

References 13 publications

Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement

Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement

L(+) and D(-) Lactate Are Increased in Plasma and Urine Samples of Type 2 Diabetes as Measured by a Simultaneous Quantification of L(+) and D(-) Lactate by Reversed-Phase Liquid Chromatography Tandem Mass Spectrometry

Increased expression of nerve growth factor correlates with visceral hypersensitivity and impaired gut barrier function in diarrhoea‐predominant irritable bowel syndrome: a preliminary explorative study

Contact Info

Product

Resources

About