Soluble chitosan–carrageenan polyelectrolyte complexes and their gastroprotective activity

Volod’ko, Aleksandra V.; Давыдова, В. Н.; Chusovitin, E. A.; Сорокина, И. В.; Долгих, М. П.; Толстикова, Т. Г.; Balagan, S. A.; Галкин, Н. Г.; Yermak, Irina M.

doi:10.1016/j.carbpol.2013.10.049

Cited by 38 publications

(22 citation statements)

References 30 publications

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“…[ 12 ]. The structure of κ-carrageenan consists of hydroxyl groups, which enables the formation of coordinate bonds with cations or protons [ 15 ]. Proton conductivity is caused by the transport of protons along the polymer structure of κ-carrageenan.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of modified κ-carrageenan for enhanced proton conductivity as polymer electrolyte membrane

et al. 2017

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Polymer electrolyte membranes based on the natural polymer κ-carrageenan were modified and characterized for application in electrochemical devices. In general, pure κ-carrageenan membranes show a low ionic conductivity. New membranes were developed by chemically modifying κ-carrageenan via phosphorylation to produce O-methylene phosphonic κ-carrageenan (OMPC), which showed enhanced membrane conductivity. The membranes were prepared by a solution casting method. The chemical structure of OMPC samples were characterized using Fourier transform infrared spectroscopy (FTIR), 1H nuclear magnetic resonance (1H NMR) spectroscopy and 31P nuclear magnetic resonance (31P NMR) spectroscopy. The conductivity properties of the membranes were investigated by electrochemical impedance spectroscopy (EIS). The characterization demonstrated that the membranes had been successfully produced. The ionic conductivity of κ-carrageenan and OMPC were 2.79 × 10−6 S cm-1 and 1.54 × 10−5 S cm-1, respectively. The hydrated membranes showed a two orders of magnitude higher ionic conductivity than the dried membranes.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of modified κ-carrageenan for enhanced proton conductivity as polymer electrolyte membrane

et al. 2017

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“…CS was mixed with various polymers with the aim of modifying the release of active ingredients, protect genes and therapeutic peptides in the GIT and improve their permeation across the intestinal epithelium and to immobilize antibodies [57][58][59]. Alginate, carrageenan, pectin, hyaluronic acid and XG are amongst the many natural polymers to be used with CS [47,60,61].…”

Section: Cs and Xg Matrices As Controlled Release Drug Delivery Systementioning

confidence: 99%

An Overview of Chitosan-Xanthan Gum Matrices as Controlled Release Drug Carriers

Dadou¹,

Antonijević²,

Chowdhry³

et al. 2018

Chitin-Chitosan - Myriad Functionalities in Science and Technology

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Naturally occurring polysaccharides and/or their chemically modified derivatives have been widely investigated in relation to their use as components of controlled release systems for drug delivery. The aforementioned is due, in part, to their distinct properties such as abundant availability and biocompatibility as well as environmental and economic advantages. Chitosan (CS) and xanthan gum (XG) based matrices have received growing scientific/pharmaceutical interest as oral controlled release drug carriers. Herein, recent advances spanning the last two decades in CS-XG based drug delivery systems are reviewed with the emphasis being on oral tablet formulations, due to their versatility as pharmaceutical dosage forms. The mechanism of interaction between CS and XG, by means of computational and experimental approaches, is scrutinized. Results obtained from the literature establish the possibility of fabricating a controlled release drug delivery system based on CS and XG matrices. This can be achieved by monitoring and manipulating the physiochemical properties of the two polymers as well as the experimental variables affecting their drug retardation efficiency, without the need to employ special equipment or sophisticated experimental techniques/methodologies.

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“…The PEC particles find wide applications in various disease conditions, including cancer (Anitha et al 2011, Martins et al 2013, HIV/AIDS (Costalat et al 2014, Polexe et al 2013, gastric ulcer (Volodko et al 2013), Staphylococci infections (Lankalapalli et al 2014), and fungal infections (Lefnaoui and Moulai-Mostefa 2014). The particulars of polycations and polyanions used, therapeutic agents loaded into, and the diseases targeted using these PECs are presented in Table 2.…”

Section: Applications Of Pecs In Drug Deliverymentioning

confidence: 99%

Polyelectrolyte complexes: mechanisms, critical experimental aspects, and applications

Kulkarni

Vanjari

Sancheti

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

126

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The polyelectrolyte complexes (PECs) are versatile formulations formed by electrostatic interactions between oppositely charged biopolymers. PECs have been investigated widely by the researchers to explore the virtues of this formulation viz. high biocompatibility, excellent biodegradability, low toxicity, cost-effective, environment-friendly, and energy-efficient production. The prime object of the present review is to present the prominent features of PECs including mechanism of PEC formation, structural models of PECs, interactions involved in PEC formation, steps involved in PEC fabrication, factors affecting the formation of PECs and applications of PECs. The patents pertaining to PECs have briefly been tabulated as well.

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Soluble chitosan–carrageenan polyelectrolyte complexes and their gastroprotective activity

Cited by 38 publications

References 30 publications

Synthesis and characterization of modified κ-carrageenan for enhanced proton conductivity as polymer electrolyte membrane

Synthesis and characterization of modified κ-carrageenan for enhanced proton conductivity as polymer electrolyte membrane

An Overview of Chitosan-Xanthan Gum Matrices as Controlled Release Drug Carriers

Polyelectrolyte complexes: mechanisms, critical experimental aspects, and applications

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