Solubilization of resveratrol in micellar solutions of different bile acids

Atanacković, Milica; Poša, Mihalj; Heinle, H.; Gojkovic-Bukarica, Ljiljana; Cvejić, Jelena

doi:10.1016/j.colsurfb.2009.03.029

Cited by 66 publications

(38 citation statements)

References 30 publications

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“…According to the ratios of the three biliary lipids, different topologies may form and vary in particle size ranging from simple micelles (1-2 nm) to MM (4-10 nm), small unilamellar vesicles (40-100 nm) and, finally, large multilamellar vesicles (300-500 nm). 11,53 Endogenous self-assembled aggregates of bile lipids were exploited by pharmaceutical researchers to fabricate BS-integrated nanocarriers, as will be discussed in the following section. …”

Section: Peculiar Structure and Self-assembled Topologiesmentioning

confidence: 99%

“…11,44,48 Nevertheless, a contradictory effect was demonstrated when exogenous bile was coadministered with oral solid formulations. 91 Administration of exogenous bile was accompanied by decreased oral bioavailability of atenolol 95 and nitrendipine.…”

Section: Paradoxical Effects Of Bsmentioning

confidence: 99%

“…1,3 In the pharmaceutical field, BSs have been exploited to improve hydrophilicity of water-insoluble active pharmaceutical ingredients (such as amphotericin B, resveratrol, and oxaprozin) mainly by the wetting effect. [11][12][13] Furthermore, BSs have been employed as permeation enhancers in topical dosage forms including buccal, ocular, nasal, and transdermal routes of administration. [14][15][16][17] Besides, the serendipitous discovery of BS gelation tendency led to their use as low-molecular-weight cationic hydrogelators.…”

Section: Introductionmentioning

confidence: 99%

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Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine

Elnaggar¹

2015

IJN

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The human body has long provided pharmaceutical science with biomaterials of interesting applications. Bile salts (BSs) are biomaterials reminiscent of traditional surfactants with peculiar structure and self-assembled topologies. In the pharmaceutical field, BSs were employed on the basis of two different concepts. The first concept exploited BSs’ metabolic and homeostatic functions in disease modulation, whereas the second one utilized BSs’ potential to modify drug-delivery characteristics, which recently involved nanotechnology. This review is the first to gather major pharmaceutical applications of BSs from endogenous organotropism up to integration into nanomedicine, with a greater focus on the latter domain. Endogenous applications highlighted the role of BS in modulating hypercholesterolemia and cancer therapy in view of enterohepatic circulation. In addition, recent BS-integrated nanomedicines have been surveyed, chiefly size-tunable cholate nanoparticles, BS-lecithin mixed micelles, bilosomes, probilosomes, and surface-engineered bilosomes. A greater emphasis has been laid on nanosystems for vaccine and cancer therapy. The comparative advantages of BS-integrated nanomedicines over conventional nanocarriers have been noted. Paradoxical effects, current pitfalls, future perspectives, and opinions have also been outlined.

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Section: Peculiar Structure and Self-assembled Topologiesmentioning

confidence: 99%

Section: Paradoxical Effects Of Bsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine

Elnaggar¹

2015

IJN

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“…Micellar solutions of bile acids allow the solubilization of poorly soluble organic substances and can improve their resorption, as these micelles are composed of bile acids, which represent bi-planar biological surfactants, with two functionally different molecular surfaces: a hydrophobic convex surface of steroid core, and a hydrophilic concave surface, representing amphiphilic molecules (Atanacković et al, 2009;Atanacković, Gojković-Bukarica, Cvejić, 2012). Furthermore, these compounds have been studied as permeability enhancers of biological membranes, such as the skin barrier, as above their critical micellar concentration (CMC), they can associate with cell membrane phospholipids and cause interruption of membrane integrity.…”

Section: Micellar Systemsmentioning

confidence: 99%

The main potentialities of resveratrol for drug delivery systems

Ruivo

Francisco

Oliveira

et al. 2015

Braz. J. Pharm. Sci.

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Resveratrol (RSV), a natural polyphenol found in grapes, was found to be effective in the prevention and therapy of several diseases, however, it does have unfavourable physicochemical properties. In this context, an increasing number of studies have aimed at developing novel therapeutic systems for its delivery to overcome these disadvantages. This review focuses on the mechanisms of action and therapeutic applications. Finally, it also describes some tested formulations for RSV administration, controlled release and targeting, developed with the purpose of increasing RSV bioavailability.Uniterms: Nutraceuticals. Natural polyphenols. Resveratrol/mechanisms of action. Resveratrol/ therapeutic applications. Resveratrol/delivery systems.O resveratrol (RSV) é um polifenol natural encontrado nas uvas, que se mostrou eficaz na prevenção e terapia de várias doenças. No entanto, apresenta propriedades físico-químicas desfavoráveis. Neste contexto, um número cada vez maior de estudos visando ao desenvolvimento de novos sistemas terapêuticos para a sua liberação vem sendo desenvolvido no sentido de ultrapassar estas desvantagens. Esta revisão discorre sobre os mecanismos de ação e aplicações terapêuticas do RSV. Finalmente, são abordadas algumas formulações de liberação controlada e vetorizada, testadas para administração do RSV, desenvolvidas com a finalidade de aumentar a biodisponibilidade do RSV. Unitermos:Nutracêuticos. Polifenóis naturais. Resveratrol/mecanismo de ação. Resveratrol/aplicações terapêuticas. Resveratrol/sistemas de liberação.

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“…This coexistence of non-polar and polar surfaces influences their physico-chemical properties [1][2][3][4] such as formation of self-association micelles that have significant role in the physiology of the metabolism of fats, absorption of liposoluble vitamins and hydrophobic drugs. Beside their physiological role, micellar solutions of bile acids can solubilizate poorly soluble organic substances [5]. Furthermore, bile acids have a promoting effect in the transport of some polar drugs [6].…”

Section: Introductionmentioning

confidence: 99%

Influence of Bile Salts as Excipients in Ranitidine, Aminophylline and Phenobarbital Tablets on Dissolution Rate

Pocuca¹,

Cvejić²,

Vukmirović³

et al. 2017

Clin Pharmacol Biopharm

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Aim: The aim of this study is to investigate the influence of bile salts, sodium cholate, sodium 12-ketocholate and sodium dehydrocholate, as excipients in ranitidine, aminophylline and phenobarbital tablets on dissolution rate.Methods: Four groups of tablets (control without bile salts and three investigational groups containing different bile salts) were prepared for three different drug substances: ranitidine, aminophylline and phenobarbital. Dissolution rate was measured.Results: Dissolution rate is increased significantly in all investigational groups comparing to the control group in all three drug substances. Discussion:Presented results are very favourable and encouraging in case of dissolution enhancing and should be further investigated, especially in drug substances that are classified in class II and IV as per Biopharmaceutical Classification System (BCS) classification. Conclusion:Bile acid salts are very promising excipients, proven to act as surfactants and as lubricants. Running title: Bile salts as excipients in ranitidine, aminophylline and phenobarbital tablets.

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Solubilization of resveratrol in micellar solutions of different bile acids

Cited by 66 publications

References 30 publications

Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine

Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine

The main potentialities of resveratrol for drug delivery systems

Influence of Bile Salts as Excipients in Ranitidine, Aminophylline and Phenobarbital Tablets on Dissolution Rate

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