“…Many flavonoids extracted from plants have been reported to show various biological effects, including anticancer, antioxidant, antibacterial, anti-inflammatory, and antidepressant effects (Ahmed, Khan, Saeed, 2015;Xie et al, 2014;Kulbacka et al, 2016;Yao et al, 2014;Keshari et al, 2016). Apigenin (5,7,4´-trihydroxyflavonoid; Figure 1), a bioflavonoid widely found in citrus fruits, has been found to exert a variety of pharmacological effects, Page 2 / 10 including antibacterial, anticancer, and antiproliferative effects (Banerjee et al, 2015;Liu et al, 2013;Eumkeb, Chukrathok, 2013;Choi et al, 2010;Turktekin et al, 2011;Ruivo et al, 2015). The prenyl moiety is widely found in many drugs and natural products (Zhao et al, 2011;Winans et al, 1999).…”