Aim: The aim of this study is to investigate the influence of bile salts, sodium cholate, sodium 12-ketocholate and sodium dehydrocholate, as excipients in ranitidine, aminophylline and phenobarbital tablets on dissolution rate.Methods: Four groups of tablets (control without bile salts and three investigational groups containing different bile salts) were prepared for three different drug substances: ranitidine, aminophylline and phenobarbital. Dissolution rate was measured.Results: Dissolution rate is increased significantly in all investigational groups comparing to the control group in all three drug substances.
Discussion:Presented results are very favourable and encouraging in case of dissolution enhancing and should be further investigated, especially in drug substances that are classified in class II and IV as per Biopharmaceutical Classification System (BCS) classification.
Conclusion:Bile acid salts are very promising excipients, proven to act as surfactants and as lubricants. Running title: Bile salts as excipients in ranitidine, aminophylline and phenobarbital tablets.
Pharmaceutical forms are equally important as pharmacodynamic effect of drug for expression of therapeutic effect. Antidotarium Nicolai was the first pharmacopoeia written in the beginning of the 12th century by Nicolaus Salernitanus. Pharmaceutical forms were not described clearly in terms of type, structure, technological process and application. Salerno’s pharmacotherapy, as it can be seen from the Antidotarium, was based on “sugar-honey pharmacy” and the only difference between pharmaceutical forms was viscosity of forms. The following forms are described in the Antidotarium: electuaria, morsuli, pillules, trochisci, sirupi, emplastra, unguenta and olea. Antidotarium Nicolai is of unique importance since it is the first attempt of systematisation of pharmaceutical forms. Although today’s criteria differ significantly from Nicolaus’s, this book still has a great value as it represents the basis for all further pharmacopoeias written many years after Antidotarium Nicolai.
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