Solubilities of 3-Methoxy-<i>N</i>-phenylaniline and 3-(Methylthio)-<i>N</i>-phenylaniline in Five Organic Solvents (285 K to 333.75 K)

Jia, Yinxia; Qian, Chao; Chen, Xinzhi; He, Chao‐Hong

doi:10.1021/je3001816

Cited by 14 publications

(20 citation statements)

References 21 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxygen atoms of tetrahydrofuran can provide a lone pair of electrons to combine with carboxyl proton of BAFBA so it can dissolve the largest amount of solute. The solubility of the remaining five solvents approximately abide by the empirical rule “like dissolves like”. , The solubility of BAFBA increases with the increasing polarity of the solvents.…”

Section: Resultsmentioning

confidence: 94%

Thermodynamic Models for Determination of the Solubility of Boc-(R)-3-Amino-4-(2, 4, 5-trifluorophenyl)butanoic acid in Different Pure Solvents and (Tetrahydrofuran + n-Butanol) Binary Mixtures with Temperatures from 280.15 to 330.15 K

et al. 2016

View full text Add to dashboard Cite

A gravimetric method was taken to measure the solubility of the Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid under atmospheric pressure in methanol, ethanol, propanol, n-butanol, ethyl acetate, and tetrahydrofuran as well as in the (tetrahydrofuran + n-butanol) mixtures from 280.15 to 330.15 K.The experiment results have proved that the rising temperature leads to increased solubility of the Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid in all selected solvents. The solid−liquid equilibrium data in pure and mixed solvents is correlated with a series of equations, including the modified Apelblat equation, the Buchowski−Ksiazaczak λh equation, CNIBS/R−K equation and the Jouyban−Acree equation. During the study, the computational values were in good agreement with the experimental results according to the calculations based on all selected equations, however, the modified Apelblat equation stood out to be the higher suitable with the higher accuracy. The thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated by the van't Hoff equation. The calculated thermodynamic parameters indicated that in each studied solvent the dissolution process of Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid is endothermic.

show abstract

Section: Resultsmentioning

confidence: 94%

Thermodynamic Models for Determination of the Solubility of Boc-(R)-3-Amino-4-(2, 4, 5-trifluorophenyl)butanoic acid in Different Pure Solvents and (Tetrahydrofuran + n-Butanol) Binary Mixtures with Temperatures from 280.15 to 330.15 K

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Moreover, the order of DCBNT solubility in different solvents is: DMSO > DEF > H 2 O > BL, by further comparing the four sets of data, and it can also be seen that the mole fraction solubility of DCBNT in DMSO is nearly 100 times higher than that in H 2 O. According to the principle of ‘like dissolves like’ [24,25], the solubility of DCBNT in H 2 O should be better than that in DMSO, so the solubility of DCBNT may not only depend upon the solvent polarity but also upon other factors. Although the solubility of DCBNT in H 2 O, DEF and BL is not so good as in DMSO, the solubility curve changes obviously with temperature, so it can also be used as an alternative solvent for cooling crystallization of DCBNT.…”

Section: Resultsmentioning

confidence: 99%

Solubility of dicarbohydrazide bis[3-(5-nitroimino-1,2,4-triazole)] in common pure solvents and binary solvents at different temperatures

Ren

Chen

et al. 2019

R. Soc. open sci.

View full text Add to dashboard Cite

The solubility of dicarbohydrazide bis[3-(5-nitroimino-1,2,4-triazole)] (DCBNT) was first measured under the different pure solvents and binary solvents by the dynamic method over the temperature range of 290–360 K at atmospheric pressure. Results in all the solvents were positively correlated with temperature, namely increased with increasing temperature. The experiment data were correlated by the Apelblat equation, the Yaws equation and the polynomial equation. The conclusion showed that these three models all agreed well with the experimental data. Simultaneously, the dissolution enthalpy, dissolution entropy and Gibbs free energy of DCBNT in different solvents were calculated from the solubility data by using the Apelblat model. The results indicate that the dissolution process of DCBNT in these solvents is driven by entropy, which provides theoretical guidance for further research on the crystallization of DCBNT.

show abstract

“…The solubility of olaparib in the remaining three solvents conformed to the "like dissolves like" principle. 13,14 The temperature dependence of olaparib solubility can be described by equation 3 and equation 4. Table 3 and Table 4 show the fitting parameters.…”

Section: Resultsmentioning

confidence: 99%

Solid–Liquid Phase Equilibrium and Thermodynamic Properties of Olaparib in Selected Organic Solvents and (Tetrahydrofuran + MTBE, Acetonitrile + Isopropyl Alcohol) Binary Solvent Mixtures

et al. 2017

View full text Add to dashboard Cite

We focused on the solubility of olaparib under atmospheric pressure in isopropyl alcohol, MTBE, acetonitrile, and tetrahydrofuran as well as in the (tetrahydrofuran + MTBE, acetonitrile + isopropyl alcohol) mixtures from 280.35− 319.35 K. It is found that the solubility of olaparib and temperature were positively correlated in the range of our study. We chose the modified Apelblat equation, the Buchowski−Ksiazaczak λh equation, CNIBS/R-K equation, and the Jouyban−Acree equation to verify the thermodynamic properties of olaparib. Computational results showed that all selected equations agreed well with the experimental data, and the modified Apelblat equation gives the best correlation. We also selected two binary solvent dissolution systems, and the test found that (tetrahydrofuran + MTBE) mixtures may be a good recrystallization system. This study provides valuable data for olaparib's production process purification.

show abstract

Solubilities of 3-Methoxy-N-phenylaniline and 3-(Methylthio)-N-phenylaniline in Five Organic Solvents (285 K to 333.75 K)

Cited by 14 publications

References 21 publications

Thermodynamic Models for Determination of the Solubility of Boc-(R)-3-Amino-4-(2, 4, 5-trifluorophenyl)butanoic acid in Different Pure Solvents and (Tetrahydrofuran + n-Butanol) Binary Mixtures with Temperatures from 280.15 to 330.15 K

Thermodynamic Models for Determination of the Solubility of Boc-(R)-3-Amino-4-(2, 4, 5-trifluorophenyl)butanoic acid in Different Pure Solvents and (Tetrahydrofuran + n-Butanol) Binary Mixtures with Temperatures from 280.15 to 330.15 K

Solubility of dicarbohydrazide bis[3-(5-nitroimino-1,2,4-triazole)] in common pure solvents and binary solvents at different temperatures

Solid–Liquid Phase Equilibrium and Thermodynamic Properties of Olaparib in Selected Organic Solvents and (Tetrahydrofuran + MTBE, Acetonitrile + Isopropyl Alcohol) Binary Solvent Mixtures

Contact Info

Product

Resources

About