Esomeprazole sodium was a proton pump inhibitor (PPI) synthesized using omeprazole sulfide. In this paper, we used a static-analytic method to analyze the solubility of our own synthesis of esomeprazole sodium in ethyl acetate, acetonitrile, methyl isobutyl ketone, ethanol, methanol, and in the (ethanol + ethyl acetate) mixtures between 278.15 and 328.15 K. A group of thermodynamic models were selected such as the Jouyban−Acree equation, the modified Apelblat equation, and CNIBS/R-K equations. All equations can be well applied and the modified Apelblat equations are relatively better. We determined the thermodynamic properties of esomeprazole sodium using the van't Hoff equation furthermore, including the entropy, Gibbs energy, and enthalpy.
In this study, the solubility of 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide (APMC) in pure tetrahydrofuran, ethyl acetate, acetonitrile, n-butanol, n-propanol, ethanol, methanol, and three binary solvent mixtures (ethyl acetate + methanol, ethyl acetate + ethanol, and ethyl acetate + n-butanol) was first experimentally determined within the temperature range from (278.15 to 328.15) K under atmosphere pressure by the gravimetric method. The results reveal that the solubility of APMC increases with an increase in temperature in all of the solvents selected. The modified Apelblat equation and the Buchowski−Ksiazaczak λh equation were used to correlate the experimental solubility in pure solvents while the modified Apelblat equation, the CNIBS/R−K model, and the Jouyban−Acree model were applied to correlate the solubility in binary solvent mixtures. All of the models could be well applied, and the modified Apelblat equation stood out to be more suitable with a higher accuracy compared to that of the other three models.
We focus on the solubility of 4-methylsulfonylacetophenone.
A gravimetric
method was taken to measure the solubility of 4-methylsulfonylacetophenone
in n-hexane, ethyl acetate, methanol, ethanol, n-propyl alcohol, n-butyl alcohol, ethylene
glycol, cyclohexane, isobutyl alcohol, and (ethyl acetate + n-hexane) binary solvent mixtures from 278.15 K to 328.15
K under atmospheric pressure. Its corresponding (solid + liquid) equilibrium
results will provide essential support for further theoretical studies.
The solubility of 4-methylsulfonylacetophenone in nine pure solvents
were correlated with λh and Apelblat models,
while 4-methylsulfonylacetophenone in (ethyl acetate + n-hexane) binary solvent mixtures were correlated with the Apelblat
and CNIBS/R–K models. The Apelblat model was proven to be the
best-fit model for correlating the solubility of both pure solvents
and binary solvents mixtures from the analysis of the STATISTIC.
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