Sol–gel preparation of Zn-doped fluoridated hydroxyapatite films

Miao, Shundong; Weng, Wenjian; Cheng, Kui; Du, Piyi; Shen, Ge; Han, Gaorong; Zhang, Sam

doi:10.1016/j.surfcoat.2004.10.026

Cited by 39 publications

(16 citation statements)

References 12 publications

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“…Antibacterial activity of silver depends on its cations, which can bind strongly with electron‐donor groups on biological molecules consisting of nitrogen, sulfur, or oxygen 41. It is accepted that heavy metals can bind to proteins by reacting with disulfide (SS) and sulfhydryl (SH) groups on proteins of cell membrane, provoking proteins, and therefore cell inactivation 10, 22, 42, 43. Ag reaction with sulfhydryl group in the cell membrane may cause formation of RSSR bonds that block respiration and electron transfer into cell 22, 30.…”

Section: Resultsmentioning

confidence: 99%

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In vitro antibacterial evaluation of sol–gel‐derived Zn‐, Ag‐, and (Zn + Ag)‐doped hydroxyapatite coatings against methicillin‐resistant Staphylococcus aureus

Samani

Hossainalipour

Tamizifar

et al. 2012

J Biomedical Materials Res

121

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Hydroxyapatite (HAp) coatings were applied using sol-gel method. Phosphor pentoxide and calcium nitrate were used as phosphorous and calcium precursors, respectively. Zinc nitrate and silver nitrate were used as substitute of calcium in HAp structure. As a base concentration, 1.5 wt %Ag and 2.5 wt %Zn were used. The weight percent of Ag was increased at 0.3 wt% and Zn content was scaled down at 0.5 wt%. Phase analysis and chemical bonds of synthesized materials were studied by XRD and FTIR. Antibacterial activity of Ag- and Zn-doped samples against methicilin-resistant Staphylococcus aureus (MRSA) were assessed by the plate-counting method. The XRD and FTIR results proved formation of HAp compound. Colony counting showed that silver and zinc ions prevent proliferation and growth of MRSA. Interestingly, co-presence of metal ions improves the antibacterial effectiveness of the coatings and the combined effect was greater than sum of the individual effects when each was administered alone. Overall, synergism between antibacterial activities of Zn(2+) and Ag(+) ions against MRSA can be suggested. Thus, cell toxicity decreases and biocompatibility increases without any decrement in antibacterial activity.

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Section: Resultsmentioning

confidence: 99%

“…Synergy between silver and other antimicrobial agents has been studied against various species of bacteria and viruses. Besides, silver has shown to have synergistic activity with other metal ions such as copper and zinc 22…”

Section: Introductionmentioning

confidence: 99%

In vitro antibacterial evaluation of sol–gel‐derived Zn‐, Ag‐, and (Zn + Ag)‐doped hydroxyapatite coatings against methicillin‐resistant Staphylococcus aureus

Samani

Hossainalipour

Tamizifar

et al. 2012

J Biomedical Materials Res

121

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“…Addition of fluorine has been found effective in retardation of the coating dissolution in SBF [6,7]. Substitution of cations like K + , Na + , Zn 2+ , Mn 2+ and Mg 2+ in the apatite structure to mimic natural bone has received much attention [8][9][10][11] to take advantage of their roles in bone metabolism, promoting catalytic reaction and controlling biological functions. Undoubtedly, magnesium is one of the most important bivalent ions associated with biological apatites [12].…”

Section: Introductionmentioning

confidence: 99%

In vitro effect of magnesium inclusion in sol–gel derived apatite

Zhang

Khor

et al. 2008

Thin Solid Films

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“…In addition, there have been several studies investigating Zn and other ions in a co-doping role, such as Zn-F (Uysal et al, 2014;Miao et al, 2005), Zn-Cu (Stanić et al, 2010), Zn-Ag (Samani et al, 2013), Zn-Mg-Sr (Cox et al, 2014) and Zn-CO 3 (Suresh Kumar et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Structural and microstructural interpretations of Zn-doped biocompatible bone-like carbonated hydroxyapatite synthesized by mechanical alloying

et al. 2015

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Single-phase nanocrystalline biocompatible Zn-doped A-type carbonated hydroxyapatite (A-cHAp) powder has been synthesized via mechanical alloying of a stoichiometric mixture of CaCO 3 , CaHPO 4 Á2H 2 O and ZnO powders in open air at room temperature by 10 h of milling. The A-type carbonation in HAp (A-cHAp) is confirmed by Fourier transform IR analysis. The structural and microstructural parameters of the as-milled powders are revealed by Rietveld powder structure refinement analysis and transmission electron microscopy. Zn substitution along with mechanical alloying causes partial amorphization of crystalline A-cHAp, analogous to native bone mineral. Zn 2+ cations substitute into the ninefold-coordinated Ca 2+ sites in the A-cHAp unit cell. An assay test using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] reveals a high percentage of cell viability and hence confirms the biocompatibility of the sample. The overall results indicate that the processed A-cHAp has a chemical composition very close to that of natural biological apatite.

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Sol–gel preparation of Zn-doped fluoridated hydroxyapatite films

Cited by 39 publications

References 12 publications

In vitro antibacterial evaluation of sol–gel‐derived Zn‐, Ag‐, and (Zn + Ag)‐doped hydroxyapatite coatings against methicillin‐resistant Staphylococcus aureus

In vitro antibacterial evaluation of sol–gel‐derived Zn‐, Ag‐, and (Zn + Ag)‐doped hydroxyapatite coatings against methicillin‐resistant Staphylococcus aureus

In vitro effect of magnesium inclusion in sol–gel derived apatite

Structural and microstructural interpretations of Zn-doped biocompatible bone-like carbonated hydroxyapatite synthesized by mechanical alloying

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