Sol-gel derived terbium-containing mesoporous bioactive glasses nanospheres: In vitro hydroxyapatite formation and drug delivery

Wang, Xiang; Zhang, Ying; Lin, Cheng-Ju; Zhong, Wenxing

doi:10.1016/j.colsurfb.2017.09.051

Cited by 51 publications

(43 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, rare-earth metals (REM) (e.g., lanthanides and scandium) and actinides have attracted great interest in the orthopaedic field due to their high biological activity and ability to replace calcium ions in HAs [1,126,340]. Different lanthanide and actinide doping in HA have been attempted, such as lanthanum (La 3+ ) [267,340,341,342,343], cerium (Ce 3+ ) [344,345,346,347,348,349], praseodymium (Pr 3+ ) [345,350,351], neodymium (Nd 3+ ) [128,345,352,353], samarium (Sm 3+ ) [354,355,356,357,358,359], europium (Eu 3+ ) [353,360,361,362,363,364,365,366,367], gadolinium (Gd 3+ ) [128,354,368], terbium (Tb 3+ ) [345,353,361,369,370], holmium (Ho 3+ ) [371], erbium (Er 3+ ) [353,372], thulium (Tm 3+ ) [360], ytterbium (Y 3+ ) [373], and uranium (U 3+ ) [374,375].…”

Section: Cation-substituted Hydroxyapatitesmentioning

confidence: 99%

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

et al. 2018

View full text Add to dashboard Cite

High-performance bioceramics are required for preventing failure and prolonging the life-time of bone grafting scaffolds and osseous implants. The proper identification and development of materials with extended functionalities addressing socio-economic needs and health problems constitute important and critical steps at the heart of clinical research. Recent findings in the realm of ion-substituted hydroxyapatite (HA) could pave the road towards significant developments in biomedicine, with an emphasis on a new generation of orthopaedic and dentistry applications, since such bioceramics are able to mimic the structural, compositional and mechanical properties of the bone mineral phase. In fact, the fascinating ability of the HA crystalline lattice to allow for the substitution of calcium ions with a plethora of cationic species has been widely explored in the recent period, with consequent modifications of its physical and chemical features, as well as its functional mechanical and in vitro and in vivo biological performance. A comprehensive inventory of the progresses achieved so far is both opportune and of paramount importance, in order to not only gather and summarize information, but to also allow fellow researchers to compare with ease and filter the best solutions for the cation substitution of HA-based materials and enable the development of multi-functional biomedical designs. The review surveys preparation and synthesis methods, pinpoints all the explored cation dopants, and discloses the full application range of substituted HA. Special attention is dedicated to the antimicrobial efficiency spectrum and cytotoxic trade-off concentration values for various cell lines, highlighting new prophylactic routes for the prevention of implant failure. Importantly, the current in vitro biological tests (widely employed to unveil the biological performance of HA-based materials), and their ability to mimic the in vivo biological interactions, are also critically assessed. Future perspectives are discussed, and a series of recommendations are underlined.

show abstract

Section: Cation-substituted Hydroxyapatitesmentioning

confidence: 99%

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Wang et al [132] effectively produced terbium-containing mesoporous bioactive glass nanospheres (Tb/MBG) by the sol-gel process. Findings have demonstrated that the developed nanospheres of Tb/MBG show excellent biocompatibility, rapid degradation, and regulated delivery of DOX.…”

Section: Bioactive Glass Drug Carriersmentioning

confidence: 99%

Sol-gel: Uncomplicated, routine and affordable synthesis procedure for utilization of composites in drug delivery: Review

Azadani

Sabbagh²,

Salehi

et al. 2021

jcc

View full text Add to dashboard Cite

“…In this regard, FTIR absorption spectra were recorded for all as-prepared samples as shown in Fig. 6 taking into account that their assignment was carried out based on the literature [17,[40][41][42][43][44]. Although the prepared BG sample is mainly consisted of two formers, i.e.…”

Section: Ftir Spectral Analysismentioning

confidence: 99%

Synthesis, Structural and Biomedical Characterization of Hydroxyapatite/Borosilicate Bioactive Glass Nanocomposites

Abulyazied

Alturki

Youness

et al. 2021

J Inorg Organomet Polym

View full text Add to dashboard Cite

In this work, a borosilicate glass sample (5SiO -45B 2 O 3 -20Na 2 O-25CaO-5Ag 2 O) was added to nano-sized carbonated hydroxyapatite (CHA) powders with different contents up to 20 wt.% to improve the bioactivity, antibacterial effect, physical and mechanical properties of the resulting nanocomposites. Then, these samples were mixed, milled with a high-energy ball mill, sintered at 700°C and subjected to Xray diffraction (XRD) technique, Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) to examine their structure, chemical composition and microstructure, respectively. Furthermore, the physical and mechanical properties of the sintered nanocomposites were also measured. Moreover, the in vitro bioactivity of the prepared nanocomposites was examined with XRD and SEM. Additionally, the antibacterial behavior of these samples was tested against E. coli and S. aureus by the disc-diffusion method. The results obtained pointed out that the sample with the highest content of BG possessed the best bioactivity, antibacterial effect, physical and mechanical properties.

show abstract

Sol-gel derived terbium-containing mesoporous bioactive glasses nanospheres: In vitro hydroxyapatite formation and drug delivery

Cited by 51 publications

References 45 publications

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

Sol-gel: Uncomplicated, routine and affordable synthesis procedure for utilization of composites in drug delivery: Review

Synthesis, Structural and Biomedical Characterization of Hydroxyapatite/Borosilicate Bioactive Glass Nanocomposites

Contact Info

Product

Resources

About