Sol−Gel Derived Nitric-Oxide Releasing Materials that Reduce Bacterial Adhesion

Nablo, Brian J.; Chen, Ta-Yung; Schoenfisch, Mark H.

doi:10.1021/ja0165077

Cited by 125 publications

(140 citation statements)

References 23 publications

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“…However, with the quickly dwindling efficacy of many systemic antibiotics and antiseptics and the speedy rise of multi-resistant nosocomial bacteria (Madkour and Tew 2008), alternative antimicrobial agents are being investigated. These include silver ions (Kumar and Münstedt 2005;Zaporojtchenko et al 2006), nitric oxide (Nablo et al 2001), bioactive antibodies (Rojas et al 2000), antimicrobial peptides (Shukla et al 2010), and some naturally occurring broad-spectrum biocidal compounds, such as essential oils (Bazaka et al 2011c,d;Low et al 2011).…”

Section: Bactericidal Coatingsmentioning

confidence: 99%

Efficient surface modification of biomaterial to prevent biofilm formation and the attachment of microorganisms

Bazaka

Jacob

Crawford

et al. 2012

Appl Microbiol Biotechnol

204

134

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Biomaterials play a fundamental role in disease management and the improvement of health care. In recent years, there has been a significant growth in the diversity, function, and number of biomaterials used worldwide. Yet, attachment of pathogenic microorganisms onto biomaterial surfaces remains a significant challenge that substantially undermines their clinical applicability, limiting the advancement of these systems. The emergence and escalating pervasiveness of antibiotic-resistant bacterial strains makes the management of biomaterial-associated nosocomial infections increasingly difficult. The conventional post-operative treatment of implant-caused infections using systemic antibiotics is often marginally effective, further accelerating the extent of antimicrobial resistance. Methods by which the initial stages of bacterial attachment and biofilm formation can be restricted or prevented are therefore sought. The surface modification of biomaterials has the potential to alleviate pathogenic biofouling, therefore preventing the need for conventional antibiotics to be applied.

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Section: Bactericidal Coatingsmentioning

confidence: 99%

Efficient surface modification of biomaterial to prevent biofilm formation and the attachment of microorganisms

Bazaka

Jacob

Crawford

et al. 2012

Appl Microbiol Biotechnol

204

134

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“…Examples are given for nitric-oxide-releasing controlled release systems (Nablo et al 2001;Dobmeier and Schoenfisch 2004). The advantage is probably that the antimicrobial activity is present even in a certain distance from the coated substrate, which could be helpful for package materials.…”

Section: Controlled Release Systemmentioning

confidence: 99%

Antimicrobial Coatings Obtained by Sol–Gel Method

Mahltig

Grethe

Haase

2016

Handbook of Sol-Gel Science and Technology

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“…Aminosilane-based sol-gels were produced by mixing variable amounts of isobutyltrimethoxysilane (BTMOS) and (3-trimethoxysilylpropyl) diethylenetriamine (DET3) [206]. Based on sol-gel chemistry, stable and tunable NO-releasing materials were fabricated by exposing sol-gels to high pressure NO gas at 5 atm for 72 h. Then DET3-NONOate sol-gels could release NO up to 24 h continuously.…”

Section: Nitric Oxide As Antimicrobial Agentmentioning

confidence: 99%

Nitric oxide based strategies for applications of biomedical devices

Yang

et al. 2015

Biosurface and Biotribology

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Since the first report describing nitric oxide (NO) in the mid-1980s, research efforts have been devoted to elucidating the pathway of NO generation and the mechanism of NO function in vivo. The worldwide expansion of NO investigations have helped advance progress in biomedical device applications of NO-based strategies for cardiovascular devices, wound healing and antimicrobial agents, including recent in vivo investigations. Here we describe the general concepts of NO discovery, mechanisms of NO synthesis in vivo and NO producing materials. Both design strategies and results are discussed and compared in release kinetics, NO dose and biological effects, with the aim of providing foundations for the development of new NO-based therapeutics. & 2015 Southwest Jiaotong University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Sol−Gel Derived Nitric-Oxide Releasing Materials that Reduce Bacterial Adhesion

Cited by 125 publications

References 23 publications

Efficient surface modification of biomaterial to prevent biofilm formation and the attachment of microorganisms

Efficient surface modification of biomaterial to prevent biofilm formation and the attachment of microorganisms

Antimicrobial Coatings Obtained by Sol–Gel Method

Nitric oxide based strategies for applications of biomedical devices

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