Nitric oxide based strategies for applications of biomedical devices

Abstract

Since the first report describing nitric oxide (NO) in the mid-1980s, research efforts have been devoted to elucidating the pathway of NO generation and the mechanism of NO function in vivo. The worldwide expansion of NO investigations have helped advance progress in biomedical device applications of NO-based strategies for cardiovascular devices, wound healing and antimicrobial agents, including recent in vivo investigations. Here we describe the general concepts of NO discovery, mechanisms of NO synthesis in vivo and NO producing materials. Both design strategies and results are discussed and compared in release kinetics, NO dose and biological effects, with the aim of providing foundations for the development of new NO-based therapeutics. & 2015 Southwest Jiaotong University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy

“…PECAM is specifically and constitutively expressed by all ECs that promotes EC migration and angiogenesis, functions as primary EC mechanosensor, and is responsible for stabilizing EC cell-cell junctions [41]. The eNOS has a protective function in the cardiovascular system, which is attributed to NO production [22]. While basal signaling of FGFs promotes junctional integrity in ECs via stabilization of VE-cadherin and catenins [42], Hep enhanced the expression of all four tested genes compared to the SS control.…”

“…Unfortunately, the stenting process inevitably damages ECs, accompanied by impaired eNOS activity and insufficient NO production [18]. Although numerous NO-releasing/generating coatings, mostly by introducing NO supplier or catalyzer (like N-diazeniumdiolate or ascorbic acid) [10,19,20], have been developed to restore EC functions, these strategies have potential issues including the indetermination on precise therapeutic dosage as well as short half-life of NO supplier [21,22]. Moreover, the amount of released NO may be compromised when deactivated by reactive oxygen species (ROS) during the EC repopulation after stenting.…”

Development of Cu-Modified PVC and PU for Catalytic Generation of Nitric Oxide

“…However, despite the progress that has been achieved in improving haemocompatibility of implantable biomaterials their long-term clinical applications still poses a problem [2]. The surface modification of the commercialized polymers is an efficient and cost effective approach to improving their haemocompatibility in comparison to creating new biomaterials [3]. During the recent decades, a number of biomaterials which release nitric oxide (NO) from the surface have been developed.…”

Electrospun PCL/keratin/AuNPs mats with the catalytic generation of nitric oxide for potential of vascular tissue engineering

“…Nitric oxide (NO) plays a pivotal role in the cardiovascular system as it influences important pathways of cardiovascular homeostasis, inhibits vascular smooth muscle cell (SMC) proliferation, inhibits platelet activation and aggregation, and prevents atherosclerosis . NO‐releasing and NO‐generating materials for vascular applications have been developed over the past two decades . For the former, they have some significant challenges such as NO donor stability, low release capacity, and prolonged and sustained release.…”

“…14 NO-releasing and NOgenerating materials for vascular applications have been developed over the past two decades. [15][16][17][18] For the former, they have some significant challenges such as NO donor stability, low release capacity, and prolonged and sustained release. To address these issues, NO-generating materials are more attractive.…”