Sodium Orthovanadate and Trigonella Foenum Graecum Prevents Neuronal Parameters Decline and Impaired Glucose Homeostasis in Alloxan Diabetic Rats

Kumar, Pardeep; Taha, Asia; Kumar, Nitin; Kumar, Vinod; Baquer, Najma Zaheer

doi:10.14712/23362936.2015.51

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…CM was prepared from the media culture at the passage 3 of human umbilical cord mesenchymal cells culture [ 12 ]. Type 1 diabetes mellitus condition was made using single dose intramuscular injection of 125 mg of alloxan monohydrate per kg body weight [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

The structural and functional recovery of pancreatic β-cells in type 1 diabetes mellitus induced mesenchymal stem cell-conditioned medium

Nugroho¹,

Kusindarta²,

Susetya³

et al. 2016

Vet World

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Aim:Various studies have shown that secreted factors alone in culture medium without stem cell are capable of repairing tissues by itself in various conditions involving damaged tissue/organ. Therefore, this study was aimed to investigate the role of human umbilical cord mesenchymal stem cell-derived conditioned medium (CM) on the recovery of pancreatic β-cells in Wistar rats (Rattus norvegicus) with type 1 diabetes mellitus.Materials and Methods:The 0.05 ml CM induction was applied to the diabetic group of rats in weeks 1, 2, 3, and 4. 1 week after each CM induction, insulin concentration was analyzed using ELISA. The pancreas was divided into 3 regions, processed by paraffin method, stained with hematoxylin-eosin, and immunohistochemical method for insulin.Results:This study indicated the decrease in the total number of islets and insulin concentration after the injection of single dose of alloxan. The exocrine acini were also damaged. Microscopic observation detected the presence of small islets in the diabetic group 1 week after the first 0.05 ml CM induction. The number and size of the islets increased in line with the CM doses and time of inductions. Immunohistochemically, the presence of low intensity of insulin-positive cells could be recognized at the splenic and duodenal regions of the pancreas, but not gastric region, 1 week after the first and second 0.05 ml CM induction. The intensity of staining and the number of insulin-positive cells increased dramatically in 1 week after the third and fourth 0.05 ml of CM induction in all regions of the pancreas. The data of insulin blood concentration showed clear differences between the second and the fourth induction of 0.05 ml CM induction.Conclusions:This study showed very strong evidence on the role of human umbilical cord mesenchymal stem cell-derived CM in recovering the pancreatic β-cells damage in Wistar rats (R. norvegicus) with type 1 diabetes mellitus, structurally and functionally.

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Section: Methodsmentioning

confidence: 99%

The structural and functional recovery of pancreatic β-cells in type 1 diabetes mellitus induced mesenchymal stem cell-conditioned medium

Nugroho¹,

Kusindarta²,

Susetya³

et al. 2016

Vet World

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“…Additionally, 3 studies 2 , 16 , 43 were on mice species. Rat’s mean weight was 175 g and mice’s mean weight was 26.5 g. Sources of vanadium consumed for administration were vanadyl sulfate (20 studies), 2 , 12 , 17 , 18 , 21 , 39 - 42 , 44 , 48 - 51 , 53 , 54 , 57 , 58 , 60 sodium orthovanadate (10 studies), 6 , 8 , 11 , 19 , 22 , 37 , 46 , 62 - 64 oxovanadium (IV) complex (1 study), 2 vanadium pentoxide (2 studies), 20 Na[(O2)2(2,2’-bpy)] • 8 H2O vanadium complexes (1 study), 13 vanadyl(IV)-ascorbate (VOAsc) complex (1 study), 43 dioxidovanadium cis-[VO2(obz)py]) complex (1 study), 38 NaVO3 (3 studies), 21 , 47 vanadium-3-hydroxy flavone complex (1 study), 59 macrocyclic binuclear oxovanadium (IV) complex (MBOV) (1 study), 14 bis(maltolato)oxovanadium (IV) (2 studies), 16 , 45 dioxidovanadium (1 study), 61 vanadium citrate (1 study), 24 V3dipic-Cl 21 and oxovanadium(IV) chelate [VOL] (1 study). 51 Method of administration was either by dissolving into drinking water, 6 , 8 , 11 , 16 , 17 , 19 , 21 , 22 , 24 , 37 , 40 , 41 , 44 - 47 , 57 - …”

Section: Resultsmentioning

confidence: 99%

Vanadium and biomarkers of inflammation and oxidative stress in diabetes: A systematic review of animal studies

Ghalichi

Ostadrahimi

Saghafi-Asl

2022

Health Promot Perspect

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Background: Oxidative stress has a significant role in the commencement and development of hyperglycemia. Vanadium, as a transitional metal with redox properties, enters the redox process, produces free radicals, and distracts the pro-antioxidant balance. The present animal systematic review aimed to assess the effect of vanadium supplementation on inflammation and oxidative stress biomarkers in diabetes-induced animals. Methods: A systematic search was conducted using the PubMed, Scopus, and web of science databases from 1990 to 2021, according to the inclusion and exclusion criteria. The search strategy was based on the guidelines for systematic review of animal experiments and Preferred Reporting Items for Systematic Reviews (PRISMA). Criteria for eligibility were animal-based studies, evaluating the therapeutic effects of vanadium on inflammatory and oxidative stress biomarkers in diabetes. The Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool was used for assessing the methodological quality of included studies. Results: In the present study, 341 articles were evaluated out of which 42 studies were eligible for inclusion. The majority of the studies confirmed the advantageous properties of vanadium on inflammatory and oxidative stress biomarkers. A minor risk of bias was reported, based on the SYRCLE’s tool. Conclusion: According to the findings, well-designed clinical trials are warranted to assess the long-lasting effects of various vanadium compounds on inflammatory and oxidative stress biomarkers.

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“…Fenugreek powder significantly decreased the blood glucose levels and increased serum insulin levels. The beneficial effects were more significant when fenugreek seed powder was used in combination with sodium orthovanadate .…”

Section: Biochemical Biological and Pharmacological Activitiesmentioning

confidence: 99%

A small plant with big benefits: Fenugreek (Trigonella foenum‐graecum Linn.) for disease prevention and health promotion

Venkata

Swaroop²,

Bagchi

et al. 2017

Molecular Nutrition Food Res

168

102

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Plant-derived natural products have long-standing utility toward treating degenerative diseases. It is estimated that about two-thirds of world population depend on traditional medicine for primary medical needs. Fenugreek (Trigonella foenum-graecum Linn.), a short-living annual medicinal plant belonging to Fabaceae family, is used extensively in various parts of the world as herb, food, spice, and traditional medicine. Fenugreek is considered as one of the oldest medicinal plants and its health-promoting effects have been cited in Ayurveda and traditional Chinese medicine. The investigations into the chemical composition and pharmacological actions have seen a renaissance in recent years. Extensive preclinical and clinical research have outlined the pharmaceutical uses of fenugreek as antidiabetic, antihyperlipidemic, antiobesity, anticancer, anti-inflammatory, antioxidant, antifungal, antibacterial, galactogogue and for miscellaneous pharmacological effects, including improving women's health. The pharmacological actions of fenugreek are attributed to diverse array of phytoconstituents. The phytochemical analysis reveals the presence of steroids, alkaloids, saponins, polyphenols, flavonoids, lipids, carbohydrates, amino acids, and hydrocarbons. This review aims to summarize and critically analyze the current available literature to understand the potential of fenugreek for disease prevention and health improvement with special emphasis on cellular and molecular mechanisms. Current challenges and new directions of research on fenugreek are also discussed.

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Sodium Orthovanadate and Trigonella Foenum Graecum Prevents Neuronal Parameters Decline and Impaired Glucose Homeostasis in Alloxan Diabetic Rats

Cited by 9 publications

References 33 publications

The structural and functional recovery of pancreatic β-cells in type 1 diabetes mellitus induced mesenchymal stem cell-conditioned medium

The structural and functional recovery of pancreatic β-cells in type 1 diabetes mellitus induced mesenchymal stem cell-conditioned medium

Vanadium and biomarkers of inflammation and oxidative stress in diabetes: A systematic review of animal studies

A small plant with big benefits: Fenugreek (Trigonella foenum‐graecum Linn.) for disease prevention and health promotion

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